PA1-25214 detects MMP-11 from human samples. This antibody does not cross react with other MMP family members.
PA1-25214 has been successfully used in immunoprecipitation, immunohistochemistry, ELISA, and Western blot procedures.
The PA1-25214 immunogen is a synthetic peptide corresponding to the N-terminal domain of human MMP-11.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: matrix metallopeptidase 11 (stromelysin 3); Matrix metalloproteinase-11; MMP-11; SL-3; STMY3; stromelysin III; Stromelysin-3
Gene Aliases: MMP11; SL-3; ST3; STMY3
UniProt ID: (Human) P24347
Entrez Gene ID: (Human) 4320