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Invitrogen
MMP13 Polyclonal Antibody
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Product Details
PA5-27242
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Rat,
Sheep
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human MMP13. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.56 mg/mL
Amount
56 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: NT2D1.
Predicted reactivity: Rabbit (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
MMP13 (collagense 3) plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC, and ACAN. MMP13 cleaves tripal helical collagens, including type I, II, and III collagen - but has the highest activity with soluble type II collagen. It can degrade collagen type IV, XIV, and X. MMP13 plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization, and ossification. It is required for normal embryonic bone development and ossificaiton. Mutations affecting the gene can lead to spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Collagenase; Collagenase 3; collagenase-1; Collagenase-3; Collagenase3; interstitial collagenase; matrix metallo protease; matrix metalloproteinase 13; matrix metalloproteinase 13 (collagenase 3); Matrix metalloproteinase-13; MMP; MMP-13; MMPs; Procollagenase 3; UMRCASE; unnamed protein product
Gene Aliases: Clg; CLG3; MANDP1; MDST; MMP-13; Mmp1; MMP13
UniProt ID: (Human) P45452, (Mouse) P33435
Entrez Gene ID: (Human) 4322, (Mouse) 17386, (Rat) 171052
endopeptidase activity
metalloendopeptidase activity
serine-type endopeptidase activity
calcium ion binding
collagen binding
peptidase activity
metallopeptidase activity
zinc ion binding
hydrolase activity
metal ion binding
fibronectin binding
calcium-dependent protein binding
low-density lipoprotein particle receptor binding
metalloprotease
endochondral ossification
growth plate cartilage development
proteolysis
extracellular matrix disassembly
extracellular matrix organization
bone mineralization
collagen catabolic process
bone morphogenesis
response to amyloid-beta
receptor internalization
peptide catabolic process
cellular protein metabolic process
cartilage development
ossification
luteolysis
response to hypoxia
response to mechanical stimulus
embryonic hindlimb morphogenesis
response to drug
response to estrogen
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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