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Invitrogen
MMP14 Polyclonal Antibody
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FIGURE: 1 / 7
MMP14 Antibody (PA5-104459) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded MMP14 in human Oral squamous cell carcinoma sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with MMP14 polyclonal antibody (Product # PA5-104459) using a dilution of 1:200 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-104459
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Bovine
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MMP14(Accession P50281), corresponding to amino acid residues Q489-A539.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total MMP14.
Target Information
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EC 3.4.24.80; matrix metallo protease; matrix metallopeptidase 14 (membrane-inserted); matrix metalloproteinase 14 (membrane-inserted); matrix metalloproteinase 14 membrane-inserted; matrix metalloproteinase 14, membrane-inserted; Matrix metalloproteinase-14; membrane type 1 metalloprotease; membrane type 1-matrix metalloproteinase; Membrane type 1-MMP; Membrane-type matrix metalloproteinase 1; Membrane-type-1 matrix metalloproteinase; MMP; MMP-14; MMP-X MT-MMP; MMP-X1; MMPs; MT-MMP; MT-MMP 1; MT-MMP MT1-MMP; MT1-MMP; MT1MMP; MTMMP1; type 1 matrix metalloprotease 14
Gene Aliases: AI325305; MMP-14; MMP-X1; MMP14; MT-MMP; MT-MMP 1; MT-MMP-1; MT1-MMP; MT1MMP; Mtmmp; MTMMP1; sabe; WNCHRS
UniProt ID: (Human) P50281, (Mouse) P53690, (Rat) Q10739
Entrez Gene ID: (Human) 4323, (Mouse) 17387, (Rat) 81707
metalloendopeptidase activity
serine-type endopeptidase activity
integrin binding
calcium ion binding
protein binding
zinc ion binding
peptidase activator activity
transcription factor activity, sequence-specific DNA binding
peptidase activity
metallopeptidase activity
hydrolase activity
metal ion binding
metalloprotease
angiogenesis
ovarian follicle development
response to hypoxia
endothelial cell proliferation
endochondral ossification
proteolysis
response to oxidative stress
male gonad development
response to mechanical stimulus
response to hormone
positive regulation of myotube differentiation
positive regulation of peptidase activity
response to organic cyclic compound
extracellular matrix disassembly
positive regulation of cell growth
lung development
positive regulation of cell migration
collagen catabolic process
zymogen activation
endodermal cell differentiation
chondrocyte proliferation
astrocyte cell migration
response to estrogen
positive regulation of B cell differentiation
negative regulation of Notch signaling pathway
embryonic cranial skeleton morphogenesis
branching morphogenesis of an epithelial tube
tissue remodeling
negative regulation of focal adhesion assembly
craniofacial suture morphogenesis
ossification
regulation of transcription, DNA-templated
cell migration
bone development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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