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Invitrogen
MMP15 (Cleaved Tyr132) Polyclonal Antibody
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FIGURE: 1 / 1
MMP15 (Cleaved Tyr132) Antibody (PA5-76128) in WB
Western blot analysis of MMP15 in Lane 1: MCF-7 whole cell lysate (40 µg), Lane 2: SGC7901 whole cell lysate (40 µg), Lane 3: HCT116 whole cell lysate (40 µg), Lane 4: HEK293T whole cell lysate (40 µg). Samples were incubated with MMP15 polyclonal antibody (Product # PA5-76128) at a dilution of 1:500.
Product Details
PA5-76128
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 100-150 of Human MMP-15.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
MMP15 (matrix metallopeptidase 15), also known as MT2-MMP, is a member of the membrane-type matrix metalloproteinases characterized by their ability to degrade components of the extracellular matrix. It is encoded by the MMP15 gene, located on chromosome 16q12.2. Structurally, this enzyme is a type I transmembrane protein, composed of a signal peptide, a propeptide, a catalytic domain, a hemopexin-like domain, a transmembrane domain, and a cytoplasmic tail. The cleavage of the propeptide is crucial for its activation to degrade various substrates. The specific cleavage at Tyr132 is significant for its regulatory mechanisms in different physiological and pathological processes, including tissue remodeling, cancer progression, and metastasis. MMP15 has been implicated in cancer, where its expression levels correspond with the disease state and can influence cancer cell invasion and angiogenesis by modifying the extracellular environment and cellular interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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