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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to amino acids 434-448 of human MMP17|
|Storage buffer||PBS, pH 7.2|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Western Blot (WB)||Assay-dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-32162 detects MMP17 from human samples.
PA1-32162 has been successfully used in immunohistochemistry (paraffin tissue) applications.
The PA1-32162 immunogen is: Synthetic peptide - amino acids 434-448 of human MMP17
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
matrix metallopeptidase 17 (membrane-inserted); matrix metalloproteinase 17 (membrane-inserted); membrane-type matrix metalloproteinase 4; membrane-type-4 matrix metalloproteinase; MT-MMP 4; MT4-MMP
MMP-17; MMP17; MT4-MMP; MT4MMP; MTMMP4