PA5-28219 targets MMP17 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-28219 immunogen is recombinant fragment corresponding to a region within amino acids 109 and 438 of Human MMP17.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage.
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Protein Aliases: matrix metallopeptidase 17 (membrane-inserted); matrix metalloproteinase 17 (membrane-inserted); Matrix metalloproteinase-17; Membrane-type matrix metalloproteinase 4; Membrane-type-4 matrix metalloproteinase; MMP-17; MT-MMP 4; MT4-MMP; MT4MMP; MTMMP4
Gene Aliases: MMP-17; MMP17; MT4-MMP; MT4MMP; MTMMP4
UniProt ID: (Human) Q9ULZ9
Entrez Gene ID: (Human) 4326