Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
FIGURE: 1 / 2
This antibody detects endogenous protein at a molecular weight of 37 and 44 kDa.
Purity is >95% by SDS-PAGE.
Matrix metalloproteinases (MMPs) are highly homologous Zn2+ endopeptidases involved in extracellular matrix breakdown. MMP mediated extracellular remodeling occurs in normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, including arthritis and metastasis. MMP-23 exhibits sequence similarity with most MMPs, but displays a difference in domain structure. The MMP-23 protein contains prepro-, catalytic, cysteine-rich, Interleukin-1 receptor-related and proline-rich domains. Lacking a recognizable signal sequence, MMP-23 has a short prodomain. In addition, MMP-23 contains a single cysteine residue that can be part of the cysteine-switch mechanism operation for maintaining enzyme latency. MMP-23 is a membrane-anchored glycoprotein with type II topology. Subcellular localization is predominantly perinuclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Femalysin; matrix metalloproteinase 22; matrix metalloproteinase 23B; matrix metalloproteinase in the female reproductive tract; Matrix metalloproteinase-21; Matrix metalloproteinase-22; Matrix metalloproteinase-23; MIFR-1; MMP 23; MMP-21; MMP-22; MMP-23; MMP23; soluble form
Gene Aliases: MIFR; MIFR-1; MMP21; MMP22; MMP23A; MMP23B
UniProt ID: (Human) O75900
Entrez Gene ID: (Human) 8511, (Human) 8510
Molecular Function: metalloprotease
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