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Invitrogen
MMP24 Polyclonal Antibody
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FIGURE: 1 / 3
MMP24 Antibody (PA5-100202) in ICC/IF
Immunofluorescent analysis of MMP24 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and MMP24 polyclonal antibody (Product # PA5-100202) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Product Details
PA5-100202
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MMP24(Accession Q9Y5R2), corresponding to amino acid residues F442-K492.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total MMP24.
Target Information
All cells within tissues are surrounded by an extracellular matrix (ECM) giving the tissues shape and structure. The ECM is constantly being remodeled and constant communication is maintained between cells through this matrix. Secreted proteins, termed matrix metalloproteinases (MMPs), are involved in the modulation of cell-matrix interactions. MMPs are Zn (2+)-binding endopeptidases that degrade various components of the ECM. MMPs are enzymes implicated in normal and pathologic tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. These enzymes are very potent when active, and are associated with extracellular space inhibitors called TIMPs (tissue inhibitors of matrix metalloproteinases). TIMPs have been shown to block tumor cell invasion suggesting that they act as metastasis suppressor genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: matrix metallo protease; matrix metallopeptidase 24 (membrane-inserted); matrix metalloproteinase 24; matrix metalloproteinase 24 (membrane-inserted); Matrix metalloproteinase-21; Matrix metalloproteinase-24; membrane type 5-MMP; membrane-type 5 matrix metalloproteinase; Membrane-type matrix metalloproteinase 5; Membrane-type-5 matrix metalloproteinase; MMP; MMP-21; MMP-24; MMPs; MT-MMP 5; MT5-MMP; RP4-614O4.10
Gene Aliases: AU040325; MMP-24; Mmp21; MMP24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP; MT5MMP; MTMMP5
UniProt ID: (Human) Q9Y5R2, (Rat) Q99PW6, (Mouse) Q9R0S2
Entrez Gene ID: (Human) 10893, (Rat) 83513, (Mouse) 17391
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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