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Invitrogen
MMP24 Polyclonal Antibody
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FIGURE: 1 / 1
MMP24 Antibody (PA5-51333) in WB
Western Blot analysis of MMP24 was performed using Lane 1-2: 293T and HepG2 cells. The membrane was probed with MMP24 Polyclonal Antibody (Product # PA5-51333) at 1:200 dilution. Secondary antibody: Goat anti rabbit IgG at 1:8,000 dilution. Exposure time: 40 seconds.
Product Details
PA5-51333
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide of human MMP24
Conjugate
Form
Liquid
Concentration
1.3 mg/mL
Amount
130 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total MMP24 protein.
Target Information
All cells within tissues are surrounded by an extracellular matrix (ECM) giving the tissues shape and structure. The ECM is constantly being remodeled and constant communication is maintained between cells through this matrix. Secreted proteins, termed matrix metalloproteinases (MMPs), are involved in the modulation of cell-matrix interactions. MMPs are Zn (2+)-binding endopeptidases that degrade various components of the ECM. MMPs are enzymes implicated in normal and pathologic tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. These enzymes are very potent when active, and are associated with extracellular space inhibitors called TIMPs (tissue inhibitors of matrix metalloproteinases). TIMPs have been shown to block tumor cell invasion suggesting that they act as metastasis suppressor genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: matrix metallo protease; matrix metallopeptidase 24 (membrane-inserted); matrix metalloproteinase 24; matrix metalloproteinase 24 (membrane-inserted); Matrix metalloproteinase-21; Matrix metalloproteinase-24; membrane type 5-MMP; membrane-type 5 matrix metalloproteinase; Membrane-type matrix metalloproteinase 5; Membrane-type-5 matrix metalloproteinase; MMP; MMP-21; MMP-24; MMPs; MT-MMP 5; MT5-MMP; MT5-MMP variant; RP4-614O4.10
Gene Aliases: AU040325; MMP-24; Mmp21; MMP24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP; MT5MMP; MTMMP5
UniProt ID: (Human) Q9Y5R2, (Rat) Q99PW6, (Mouse) Q9R0S2
Entrez Gene ID: (Human) 10893, (Rat) 83513, (Mouse) 17391
proteolysis
cell adhesion
glial cell differentiation
extracellular matrix organization
collagen catabolic process
cell-cell adhesion mediated by cadherin
detection of temperature stimulus involved in sensory perception of pain
neuronal stem cell population maintenance
cell-cell adhesion via plasma-membrane adhesion molecules
cell-cell adhesion
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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