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Invitrogen
MMP25 Polyclonal Antibody
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Product Details
PA5-90790
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
2.7 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: A-549, HT-29, Mouse lung, Mouse liver, Rat liver; Cellular Location: Cell membrane, Extracellular side, GPI-anchor, Lipid-anchor, extracellular matrix, extracellular space
Target Information
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Leukolysin; matrix metallo protease; matrix metallopeptidase 25; matrix metallopeptidase-like 1; matrix metalloproteinase 20; matrix metalloproteinase 25; Matrix metalloproteinase-25; matrix metalloproteinase-like 1; membrane-type 6 matrix metalloproteinase; Membrane-type matrix metalloproteinase 6; Membrane-type-6 matrix metalloproteinase; MMP; MMP 25; MMP-25; MMPs; MT MMP 6; MT-MMP 6; MT6 MMP; MT6-MMP
Gene Aliases: F730048C11Rik; Leukolysin; MMP-25; MMP20; MMP20A; MMP25; MMPL1; MT-MMP 6; MT-MMP6; MT6-MMP; MT6MMP; MTMMP6
UniProt ID: (Human) Q9NPA2, (Mouse) Q3U435
Entrez Gene ID: (Human) 64386, (Rat) 302963, (Mouse) 240047
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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