PA1-25276 detects MMP-26 from human samples.
PA1-25276 has been successfully used in Western blot procedures.
The PA1-25276 immunogen is a synthetic peptide corresponding to the propeptide domain of human MMP-26.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein degrades type IV collagen, fibronectin, fibrinogen, casein, vitronectin, alpha 1-antitrypsin, alpha 2-macroglobulin, and insulin-like growth factor-binding protein 1, and activates MMP9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Endometase; matrilysin 2; Matrilysin-2; matrix metalloproteinase 26; Matrix metalloproteinase-26; MGC126590; MGC126592; MMP-26
Gene Aliases: MMP26
UniProt ID: (Human) Q9NRE1
Entrez Gene ID: (Human) 56547