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Invitrogen
MMP3 Polyclonal Antibody
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Product Details
PA5-86184
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide, corresponding to amino acids 411-460 of Human MMP-3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
MMP3 (stromelysin-1) belongs to the peptidase M10A subfamily. It is secreted in its pro-protein form, and is activated by extracellular proteinase cleavage. MMP3 is capable of binding to zinc and calcium ions, and has metallo-endopeptidase activity. The active enzyme degrades collagen, gelatin, fibronectin, and laminin. It is involved in normal cellular processes such as wound repair and tissue remodeling. Mutations in the gene can result in coronary heart disease 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 3.4.24.17; EMS-2; matrix metallo protease; matrix metalloproteinase 3; matrix metalloproteinase 3 (stromelysin 1, progelatinase); Matrix metalloproteinase-3; MMP; MMP-3; MMPs; progelatinase; proteoglycanase; SL-1; stromelysin 1; Stromelysin-1; Stromelysin1; Transin-1; Transin1
Gene Aliases: CHDS6; MMP-3; MMP3; SL-1; SLN-1; SLN1; STMY; STMY1; STR-1; STR1
UniProt ID: (Human) P08254, (Mouse) P28862
Entrez Gene ID: (Human) 4314, (Mouse) 17392, (Rat) 171045
proteolysis
negative regulation of hydrogen peroxide metabolic process
extracellular matrix disassembly
collagen catabolic process
positive regulation of protein oligomerization
cellular response to nitric oxide
positive regulation of oxidative stress-induced cell death
protein catabolic process
regulation of cell migration
positive regulation of cell migration
negative regulation of protein kinase B signaling
cellular response to amino acid stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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