|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Contains||<0.05% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||1:25-1:50|
|Immunohistochemistry (Paraffin) (IHC (P))||1:25-1:50|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
PA1-26608 detects MMP-7 from human samples.
PA1-26608 has been successfully used in immunohistochemistry (paraffin) procedures. This antibody detects a ~28 kDa band representing the pro form, and an ~18 kDa band representing the active form. No special pretreatment is required for immunostaining. Placenta tissues can be used as a positive control.
The PA1-26608 immunogen is MMP-7.
Matrix metalloproteinase (MMPs) are a family of closely related zinc-containing proteolytic enzymes, capable of degrading connective tissue components. Imbalanced secretion of certain MMP is implicated in the invasive potential of malignant tumors. MMP 7 is thought to play an important role in the early steps of tumor progression. Expression of MMP 2, MMP 7, and MMP 11 is higher in pancreatic carcinoma than in normal pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Human||1:100, 1:400, 1:5000||
Molecular and prognostic distinction between serous ovarian carcinomas of varying grade and malignant potential.
PA1-26608 was used in immunohistochemistry to distinguish low malignant potential serous ovarian carcinomas from invasive counterparts
|Meinhold-Heerlein I,Bauerschlag D,Hilpert F,Dimitrov P,Sapinoso LM,Orlowska-Volk M,Bauknecht T,Park TW,Jonat W,Jacobsen A,Sehouli J,Luttges J,Krajewski M,Krajewski S,Reed JC,Arnold N,Hampton GM||Oncogene (24:1053)||2005|