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Invitrogen
MMP7 Polyclonal Antibody
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FIGURE: 1 / 8
MMP7 Antibody (PA5-87486) in ICC/IF
Immunofluorescence analysis of MMP7 was performed using 70% confluent log phase HT-29 cells treated with Protein Transport Inhibitor (1 µM) for 4 hours. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with MMP7 Polyclonal Antibody (Product # PA5-87486) at 1:200 in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Recombina... View More
Product Details
PA5-87486
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide
Conjugate
Form
Liquid
Concentration
0.65 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: HT-29; Cellular Location: extracellular matrix, extracellular space
Immunogen sequence: VPDVAEYSLF PNSPK
Target Information
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22. 3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HGNC:7174; Matrilysin; Matrin; matrix metallo protease; matrix metallopeptidase 7 (matrilysin, uterine); Matrix metalloproteinase 7 (matrilysin); matrix metalloproteinase 7 (matrilysin, uterine); Matrix metalloproteinase-7; MMP; MMP 7; MMP-7; MMPs; PUMP 1; Pump 1 protease; Pump-1 protease; uterine matrilysin; Uterine metalloproteinase
Gene Aliases: MMP-7; MMP7; MPMM; MPSL1; PUMP-1; PUMP1
UniProt ID: (Human) P09237, (Rat) P50280
Entrez Gene ID: (Human) 4316, (Rat) 25335
proteolysis
aging
extracellular matrix disassembly
collagen catabolic process
response to nutrient levels
estrous cycle
maternal process involved in female pregnancy
cellular response to mechanical stimulus
antibacterial peptide secretion
antibacterial peptide biosynthetic process
regulation of cell proliferation
response to drug
defense response to bacterium
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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