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MMP9 Polyclonal Antibody, HRP

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MMP9 Polyclonal Antibody, HRP

Product Details

BS-22503R-HRP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300-1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-
Product Specifications

Species Reactivity

Bovine, Dog, Horse, Human, Mouse, Sheep, Pig

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human MMP9
3D Epitope / Immunogen

Conjugate

HRP HRP HRP

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS with 1% BSA, 50% glycerol

Contains

0.03% ProClin 300

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

MMP9 (matrix metallopeptidase 9, GELB, CLG4B) is a matrix metalloproteinase, a family of zinc and calcium-dependent endopeptidases that degrade extracellular matrix proteins. MMP9 is secreted as a 92kDa zymogen and cleavage of pro-MMP9 results in the active enzyme with a molecular weight of 82kDa. MMP9 has a gelatin-binding domain consisting of three fibronectin type II units, a catalytic domain containing the zinc-binding site, a proline-rich type V collagen-homologous domain and a hemopexin-like domain. MMP9 is produced by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts and endothelial cells, and is involved in inflammatory responses, tissue remodeling, wound healing, tumor growth and metastasis. MMP9 is supplied by bone marrow-derived cells and contributes to skin carcinogenesis. Further, MMP9 degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. Studies have shown that elevated MMP9 is associated with progression of idiopathic atrial fibrillation and aortic aneurysm.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 92 kDa gelatinase; 92 kDa type IV collagenase; 92kD gelatinase; 92kD type IV collagenase; 92kDa gelatinase; 92kDa type IV collagenase; collagenase type IVB; Gel B; Gelatinase B; gelatinase B; 92kDa gelatinase; 92kDa type IV collagenase; MMP9; Gelatinase-B; GELB; macrophage gelatinase; matrix metallo protease; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase 9; matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase 9 (gelatinase B, 92kDa matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); Matrix metalloproteinase-9; Matrix metalloproteinase9; MMP; MMP-9; MMP-9 proprotein; MMP-9; matrix metalloproteinase 9; MMP9; MMPs; type IV collagenase; type IV collagenase MMP-9; type IV MMP-9; type V collagenase; unnamed protein product

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Gene Aliases: AW743869; B/MMP9; CLG4B; GELB; MANDP2; MMP-9; MMP9; pro-MMP-9

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UniProt ID: (Bovine) P52176, (Human) P14780, (Mouse) P41245

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Entrez Gene ID: (Bovine) 282871, (Horse) 100056599, (Sheep) 100192422, (Dog) 403885, (Pig) 654325, (Human) 4318, (Mouse) 17395

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Function(s)
metalloendopeptidase activity peptidase activity zinc ion binding identical protein binding endopeptidase activity serine-type endopeptidase activity protein binding collagen binding metallopeptidase activity hydrolase activity metal ion binding fibronectin binding protein complex binding metalloprotease
Process(es)
skeletal system development positive regulation of protein phosphorylation proteolysis embryo implantation cellular response to reactive oxygen species endodermal cell differentiation positive regulation of DNA binding positive regulation of epidermal growth factor receptor signaling pathway positive regulation of keratinocyte migration cellular response to cadmium ion positive regulation of release of cytochrome c from mitochondria positive regulation of receptor binding response to amyloid-beta positive regulation of vascular smooth muscle cell proliferation negative regulation of epithelial cell differentiation involved in kidney development negative regulation of intrinsic apoptotic signaling pathway negative regulation of cation channel activity negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway collagen catabolic process apoptotic process cell migration extracellular matrix disassembly extracellular matrix organization macrophage differentiation positive regulation of apoptotic process negative regulation of apoptotic process ephrin receptor signaling pathway regulation of multicellular organismal process cellular response to lipopolysaccharide cellular response to UV-A regulation of neuroinflammatory response negative regulation of cation transmembrane transport ossification positive regulation of leukocyte migration response to oxidative stress transformation of host cell by virus positive regulation of synaptic plasticity response to drug positive regulation of angiogenesis negative regulation of fibroblast proliferation tissue remodeling leukocyte migration protein oligomerization cellular response to cell-matrix adhesion
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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