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MMP9 Polyclonal Antibody
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Product Details
OSM00094W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 650-700 of mouse MMP9 conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: Matrix Metalloproteinase-9.
Target Information
MMP9 (matrix metallopeptidase 9, GELB, CLG4B) is a matrix metalloproteinase, a family of zinc and calcium-dependent endopeptidases that degrade extracellular matrix proteins. MMP9 is secreted as a 92kDa zymogen and cleavage of pro-MMP9 results in the active enzyme with a molecular weight of 82kDa. MMP9 has a gelatin-binding domain consisting of three fibronectin type II units, a catalytic domain containing the zinc-binding site, a proline-rich type V collagen-homologous domain and a hemopexin-like domain. MMP9 is produced by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts and endothelial cells, and is involved in inflammatory responses, tissue remodeling, wound healing, tumor growth and metastasis. MMP9 is supplied by bone marrow-derived cells and contributes to skin carcinogenesis. Further, MMP9 degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. Studies have shown that elevated MMP9 is associated with progression of idiopathic atrial fibrillation and aortic aneurysm.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 92 kDa gelatinase; 92 kDa type IV collagenase; 92kD gelatinase; 92kD type IV collagenase; 92kDa gelatinase; 92kDa type IV collagenase; collagenase type IVB; Gel B; Gelatinase B; Gelatinase-B; GELB; matrix metallo protease; matrix metalloproteinase 9; Matrix metalloproteinase-9; Matrix metalloproteinase9; MMP; MMP-9; MMPs
Gene Aliases: AW743869; B/MMP9; Clg4b; MMP-9; Mmp9; pro-MMP-9
UniProt ID: (Mouse) P41245
Entrez Gene ID: (Mouse) 17395
skeletal system development
ossification
positive regulation of protein phosphorylation
positive regulation of leukocyte migration
proteolysis
response to oxidative stress
embryo implantation
transformation of host cell by virus
extracellular matrix organization
collagen catabolic process
positive regulation of synaptic plasticity
response to drug
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of DNA binding
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of angiogenesis
negative regulation of fibroblast proliferation
tissue remodeling
leukocyte migration
protein oligomerization
positive regulation of keratinocyte migration
cellular response to cell-matrix adhesion
positive regulation of release of cytochrome c from mitochondria
positive regulation of receptor binding
negative regulation of intrinsic apoptotic signaling pathway
negative regulation of cation channel activity
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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