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Invitrogen
MMP9 Polyclonal Antibody
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FIGURE: 1 / 17
MMP9 Antibody (PA5-13199) in IHC (P)
Immunohistochemistry analysis of MMP9 in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with MMP9 polyclonal antibody (Product # PA5-13199) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepato... View More
Product Details
PA5-13199
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
C. elegans,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 644-673 amino acids from the C-terminal region of human MMP9
Conjugate
Form
Liquid
Concentration
0.44 mg/mL
Purification
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
MMP9 (matrix metallopeptidase 9, GELB, CLG4B) is a matrix metalloproteinase, a family of zinc and calcium-dependent endopeptidases that degrade extracellular matrix proteins. MMP9 is secreted as a 92kDa zymogen and cleavage of pro-MMP9 results in the active enzyme with a molecular weight of 82kDa. MMP9 has a gelatin-binding domain consisting of three fibronectin type II units, a catalytic domain containing the zinc-binding site, a proline-rich type V collagen-homologous domain and a hemopexin-like domain. MMP9 is produced by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts and endothelial cells, and is involved in inflammatory responses, tissue remodeling, wound healing, tumor growth and metastasis. MMP9 is supplied by bone marrow-derived cells and contributes to skin carcinogenesis. Further, MMP9 degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. Studies have shown that elevated MMP9 is associated with progression of idiopathic atrial fibrillation and aortic aneurysm.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 92 kDa gelatinase; 92 kDa type IV collagenase; 92kD gelatinase; 92kD type IV collagenase; 92kDa gelatinase; 92kDa type IV collagenase; collagenase type IVB; Gel B; Gelatinase B; Gelatinase-B; GELB; macrophage gelatinase; matrix metallo protease; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase 9; matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); Matrix metalloproteinase-9; Matrix metalloproteinase9; MMP; MMP-9; MMPs; type V collagenase
Gene Aliases: AW743869; B/MMP9; CLG4B; GELB; MANDP2; MMP-9; MMP9; pro-MMP-9
UniProt ID: (Human) P14780, (Mouse) P41245
Entrez Gene ID: (Human) 4318, (Mouse) 17395
endopeptidase activity
metalloendopeptidase activity
serine-type endopeptidase activity
protein binding
collagen binding
metallopeptidase activity
zinc ion binding
identical protein binding
fibronectin binding
peptidase activity
hydrolase activity
protein complex binding
metal ion binding
metalloprotease
skeletal system development
ossification
positive regulation of protein phosphorylation
proteolysis
embryo implantation
extracellular matrix disassembly
macrophage differentiation
collagen catabolic process
endodermal cell differentiation
negative regulation of apoptotic process
positive regulation of DNA binding
positive regulation of epidermal growth factor receptor signaling pathway
ephrin receptor signaling pathway
leukocyte migration
positive regulation of keratinocyte migration
positive regulation of release of cytochrome c from mitochondria
positive regulation of receptor binding
positive regulation of vascular smooth muscle cell proliferation
negative regulation of intrinsic apoptotic signaling pathway
negative regulation of cation channel activity
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
positive regulation of leukocyte migration
response to oxidative stress
transformation of host cell by virus
extracellular matrix organization
positive regulation of synaptic plasticity
response to drug
positive regulation of apoptotic process
positive regulation of angiogenesis
negative regulation of fibroblast proliferation
tissue remodeling
protein oligomerization
cellular response to cell-matrix adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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