Immunogen sequence: EEWPVDETKR GRDLGAYLRQ RVAQAFREGE NTQVAEPEAC DQMYESLARL HSNYYKHKYP RPRDTSFSGL SLEEYKLILS TDTLEELKEI DKGMWKKLQE KFAPKGPEED HKA; Positive Samples: MCF7, THP-1, HepG2, U251, Mouse heart, Mouse brain, Rat testis, Rat brain; Cellular Location: Mitochondrion, Mitochondrion inner membrane, Mitochondrion intermembrane space, Mitochondrion matrix, mitochondrion nucleoid
YBX1 binds to splice sites in pre-mRNA and regulates splice site selection. This protein binds and stabilizes cytoplasmic mRNA and contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. It binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as HLA class II genes. It regulates the transcription of numerous genes and promotes separation of DNA strands that contain mismatches or are modified by cisplatin. It has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro), and it may play a role in DNA repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Breast cancer-associated protein SGA-81M; cytochrome B protein synthesis 6 homolog; Mitochondrial nucleoid factor 1; Mitochondrial protein M19; Ubiquinol-cytochrome-c reductase complex assembly factor 2
Gene Aliases: 2900010M23Rik; bA6B20.2; C6orf125; Cbp6; M19; MNF1; RGD1306917; UQCC2