This antibody is predicted to react with Monkey, Mouse, Cat
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds – the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody – recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets – a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
MAP kinase-interacting serine/threonine kinases (Mnk) function in signal transduction pathways through phosphorylation of eIF4E and are directly phosphorylated by ERK or p38 MAP kinases. In human and mouse there are two Mnk genes. Mnk1 is activated by phosphorylation at Thr197 and Thr202. Mnk1 and Mnk2 are essential for the phosphorylation of eIF4E at Ser209 however they differ markedly in their activity and regulatory patterns. Mnk1 is responsible for inducible phosphorylation of eIF4E while Mnk2 is responsible for basal levels of phosphorylation. Mnk1 has been implicated in signaling in response to oxidative stress by increasing eIF4E phosphorylation upon H2O2 treatment in mice. Oxidative stress induced Mnk1 activity has also been linked to hyperproliferative diseases through the over-activation of eIF4E. Reactivity with Mnk2 has not been tested.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MAP kinase signal-integrating kinase 1; MAP kinase-interacting serine/threonine-protein kinase 1; MAPK signal-integrating kinase 1
Gene Aliases: 2410048M24Rik; MKNK1; MNK1