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Invitrogen
MORF Polyclonal Antibody
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Product Details
PA5-37101
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to residues in human KAT6B
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 231 kDa.
Purity is >95% by SDS-PAGE.
Target Information
MOZ (monocytic leukemia zinc finger protein) is a chromatin-associated histone acetyltransferase (HAT) that regulates chromatin remodeling and transcription. The MOZ gene was initially isolated as a consequence of two variant translocations that were identified in a distinct subtype of acute myeloid leukemias and resulted in the formation of MOZ fusion proteins. These fusions involve the HAT domain of MOZ with the activation domain of either transcriptional coactivator protein TIF2/GRIP1 or CBP, and lead to enhanced transcriptional activation by a mechanism involving aberrant histone acetylation. Additional MOZ related proteins, including MORF (MOZ related factor) and Tip60 (TAT interacting proteins 60), share significant similarities with MOZ including the putuative HAT domain. MORF also contains a strong transcriptional repression domain at its N terminus and a highly potent activation domain at the C terminus, suggesting that MORF has both HAT activity and contributes to the regulation of transcriptional activation. Tip60 was originally identified as a coactivator for the HIV TAT protein and also functions as a nuclear hormone receptor coactivator that enhances ligand dependent steroid receptor-mediated transactivation involving the androgen, estrogen and progesterone receptors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Histone acetyltransferase KAT6B; histone acetyltransferase MORF; Histone acetyltransferase MOZ2; histone acetyltransferase MYST4; histone acetyltransferase querkopf; K(lysine) acetyltransferase 6B; KIAA0383; monocytic leukemia; Monocytic leukemia zinc finger protein-related factor; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4; MOZ-related factor; MOZ-related factor (MORF) alpha; similar to monocytic leukemia zinc finger protein; MOZ-related factor (MORF) beta; similar to monocytic leukemia zinc finger protein; MYST family member; MYST histone acetyltransferase (monocytic leukemia) 4; MYST histone acetyltransferase monocytic leukemia 4; MYST-4; Protein querkopf; SAS2; TIP60 protein 4
Gene Aliases: AI507552; B130044K16Rik; GTPTS; KAT6B; KIAA0383; mKIAA0383; MORF; MOZ2; MYST-4; MYST4; qkf; querkopf; ZC2HC6B
UniProt ID: (Human) Q8WYB5, (Mouse) Q8BRB7
Entrez Gene ID: (Human) 23522, (Mouse) 54169
DNA binding
chromatin binding
transcription cofactor activity
transcription coactivator activity
histone acetyltransferase activity
protein binding
zinc ion binding
H3 histone acetyltransferase activity
transferase activity
transferase activity, transferring acyl groups
histone acetyltransferase activity (H3-K14 specific)
macromolecular complex binding
metal ion binding
peptide-lysine-N-acetyltransferase activity
transferase activity, transferring acyl groups other than amino-acyl groups
protein complex binding
histone modifying enzyme
chromatin organization
nucleosome assembly
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of developmental process
regulation of hemopoiesis
transcription, DNA-templated
chromatin modification
histone acetylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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