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Proteintech
MOV10 Polyclonal Antibody
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Product Details
10370-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MOV10 Fusion Protein Ag0384 (869-1004 aa encoded by BC002548)
Conjugate
Form
Liquid
Concentration
0.55 mg/mL
Amount
82.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: QGQERSVIL ISTVRSSQSF VQLDLDFNLG FLKNPKRFNV AVTRAKALLI IVGNPLLLGH DPDWKVFLEF CKENGGYTGC PFPAKLDLQQ GQNLLQGLSK LSPSTSGPHS HDYLPQEREG EGGLSLQVEP EWRNEL (869-1004 aa encoded by BC002548 )
Target Information
5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol. May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). Exhibits antiviral activity against dengue virus (DENV) (PubMed:27974568). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Armitage homolog; capping protein (actin filament) muscle Z-line, alpha 1; functional spliceosome-associated protein 113; Helicase MOV-10; Moloney leukemia virus 10 protein; Mov10 RISC complex RNA helicase; Mov10, Moloney leukemia virus 10; Mov10, Moloney leukemia virus 10, homolog; Putative helicase MOV-10; unnamed protein product
Gene Aliases: C77703; Capza1; fSAP113; Gb110; KIAA1631; Mov-10; MOV10
UniProt ID: (Human) Q9HCE1, (Mouse) P23249
Entrez Gene ID: (Human) 4343, (Rat) 310756, (Mouse) 17454
biological_process
mRNA cleavage involved in gene silencing by miRNA
negative regulation of transposition, RNA-mediated
gene silencing by RNA
posttranscriptional gene silencing by RNA
gene silencing by miRNA
defense response to virus
positive regulation of mRNA catabolic process
3'-UTR-mediated mRNA destabilization
transposable element silencing by mRNA destabilization
regulation of neuron projection arborization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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