Search
Invitrogen
MPEG1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-31958
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human MPEG1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: THP-1.
Predicted reactivity: Pig (81%), Bovine (85%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The MPEG1 (Macrophage Expressed Gene 1) gene encodes a protein known as Perforin-2, which is part of the immune system and plays a crucial role in host defense mechanisms. Located on chromosome 11, MPEG1/Perforin-2 is primarily expressed in macrophages, dendritic cells, and other immune cells. The protein functions by forming pores in the membranes of pathogenic bacteria, leading to their lysis and destruction. This pore-forming capability is integral to the innate immune response, providing a rapid means to target and eliminate intracellular pathogens. MPEG1's activity contributes significantly to the antimicrobial arsenal of the innate immune system, and deficiencies in this protein can lead to increased susceptibility to infections. Ongoing research is focused on understanding how MPEG1/Perforin-2 can be leveraged or augmented to enhance immune responses and potential therapeutic applications in infectious disease and immunotherapy.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: macrophage expressed gene 1; Macrophage gene 1 protein; Macrophage-expressed gene 1 protein; MGC150002; MGC150003; P-2; perforin 2; Perforin-2; unnamed protein product
Gene Aliases: IMD77; MPEG1; Mpg-1; MPG1; MPS1; P-2
UniProt ID: (Human) Q2M385
Entrez Gene ID: (Human) 219972
adaptive immune response
immune system process
dendritic cell antigen processing and presentation
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of exogenous peptide antigen via MHC class I
defense response to bacterium
innate immune response
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
transmembrane transport
antibacterial innate immune response
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support