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EIF4EBP1 is one member of a family of translation repressor proteins. It directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DnaJ (Hsp40) homolog, subfamily C, member 2; DnaJ homolog subfamily C member 2; DnaJ homolog subfamily C member 2, N-terminally processed; M-phase phosphoprotein 11; zuotin related factor 1; Zuotin-related factor 1
Gene Aliases: DNAJC2; MPHOSPH11; MPP11; ZRF1; ZUO1
UniProt ID: (Human) Q99543
Entrez Gene ID: (Human) 27000
Molecular Function: chaperone