Immunogen sequence: LRAMNRAALE SGISTKQLTE ADLRRTVEES SRIQRGYGHY FDLCLVNSNL ERTFRELQT
The MAGUK (membrane-associated guanylate kinase homologs) family of proteins contain multiple protein-binding domains and are involved in cell junction organization, tumor suppression and signaling. The MAGUK family is divided into four subfamilies: DLG-like, ZO1-like, p55-like and LIN2-like. MPP2 (membrane protein, palmitoylated 2), also known as MAGUK p55 subfamily member 2, discs large homolog 2 or DLG2, is a 576 amino acid protein belonging to the MAGUK family that exists as three alternatively spliced isoforms. MPP2 contains one guanylate kinase-like domain, a PDZ (DHR) domain, two L27 domains and a single SH3 domain. The gene encoding MPP2 maps to the same segment of human chromosome 17 as MPP3, with whom MMP2 likely shares similar function and common structural organization.
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Protein Aliases: Discs large homolog 2; discs large, homolog 2; DKFZp761D0712; DLG2; MAGUK p55 subfamily member 2; membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2); Protein MPP2
Gene Aliases: DLG2; MPP2
UniProt ID: (Human) Q14168
Entrez Gene ID: (Human) 4355