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Invitrogen
MPRIP Polyclonal Antibody
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Product Details
PA5-54559
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MPRIP. Recombinant protein control fragment (Product #RP-93317).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RVEGHVGELG DFQVKNSQAL MCLENCREQL RSLPRASQED EQDARAASLA SVESALVSAI QALQHWPAPA HGGARAQLET GGTEENGKPA SLQQCSQSEL TEQEQVRLLS DQIALEASLI SQIADSLKNT T
Highest antigen sequence identity to the following orthologs: Mouse - 62%, Rat - 63%.
Target Information
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: M-RIP; Myosin phosphatase Rho-interacting protein; p116Rip; Rho interacting protein 3; Rho-interacting protein 3; RIP3; unnamed protein product
Gene Aliases: KIAA0864; M-RIP; MPRIP; MRIP; p116Rip; RHOIP3; RIP3
UniProt ID: (Human) Q6WCQ1
Entrez Gene ID: (Human) 23164
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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