PA5-28779 targets MPST in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-28779 immunogen is synthetic peptide corresponding to a region within amino acids 234 and 297 of Human MPST.
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This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene.
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Protein Aliases: 3-mercaptopyruvate sulfurtransferase; human liver rhodanese; MST; testicular tissue protein Li 200; tRNA thiouridin modification protein 1; TST2
Gene Aliases: MPST; MST; TST2; TUM1
UniProt ID: (Human) P25325
Entrez Gene ID: (Human) 4357