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MPV17 Polyclonal Antibody

MPV17 Antibody in Immunocytochemistry (ICC/IF)

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MPV17 Antibody (10310-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using (Product # 10310-1-AP) (MPV17 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

MPV17 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

10310-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MPV17 Fusion Protein Ag0312 (1-175 aa encoded by BC001115)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

10310-1-AP is a rabbit polyclonal antibody raised against the full-length of human MPV17.

Immunogen sequence: MALWRAYQR ALAAHPWKVQ VLTAGSLMGL GDIISQQLVE RRGLQEHQRG RTLTMVSLGC GFVGPVVGGW YKVLDRFIPG TTKVDALKKM LLDQGGFAPC FLGCFLPLVG ALNGLSAQDN WAKLQRDYPD ALITNYYLWP AVQLANFYLV PLHYRLAVVQ CVAVIWNSYL SWKAHR (1-175 aa encoded by B C001115)

Target Information

This gene encodes a mitochondrial inner membrane protein that is implicated in the metabolism of reactive oxygen species. Mutations in this gene have been associated with the hepatocerebral form of mitochondrial DNA depletion syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Inner mitochondrial membrane protein MPV17 mutant mice display increased myocardial injury after ischemia/reperfusion.

American journal of translational research

Madungwe NB,Feng Y,Imam Aliagan A,Tombo N,Kaya F,Bopassa JC

Fri May 07 00:00:00 UTC 2021

MPV17 does not control cancer cell proliferation.

PloS one

Canonne M,Wanet A,Nguyen TTA,Khelfi A,Ayama-Canden S,Van Steenbrugge M,Fattaccioli A,Sokal E,Najimi M,Arnould T,Renard P

Mon Jul 20 00:00:00 UTC 2020

Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model.

Nucleic acids research

Moss CF,Dalla Rosa I,Hunt LE,Yasukawa T,Young R,Jones AWE,Reddy K,Desai R,Virtue S,Elgar G,Voshol P,Taylor MS,Holt IJ,Reijns MAM,Spinazzola A

Fri Dec 15 00:00:00 UTC 2017

Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model.

Nucleic acids research

Moss CF,Dalla Rosa I,Hunt LE,Yasukawa T,Young R,Jones AWE,Reddy K,Desai R,Virtue S,Elgar G,Voshol P,Taylor MS,Holt IJ,Reijns MAM,Spinazzola A

Fri Dec 15 00:00:00 UTC 2017

A monoclonal antibody raised against bacterially expressed MPV17 sequences shows peroxisomal, endosomal and lysosomal localisation in U2OS cells.

BMC research notes

Weiher H,Pircher H,Jansen-Dürr P,Hegenbarth S,Knolle P,Grunau S,Vapola M,Hiltunen JK,Zwacka RM,Schmelzer E,Reumann K,Will H

Sat Feb 27 00:00:00 UTC 2016

MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria.

PLoS genetics

Dalla Rosa I,Cámara Y,Durigon R,Moss CF,Vidoni S,Akman G,Hunt L,Johnson MA,Grocott S,Wang L,Thorburn DR,Hirano M,Poulton J,Taylor RW,Elgar G,Martí R,Voshol P,Holt IJ,Spinazzola A

Fri Jan 01 00:00:00 UTC 2016

MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria.

PLoS genetics

Dalla Rosa I,Cámara Y,Durigon R,Moss CF,Vidoni S,Akman G,Hunt L,Johnson MA,Grocott S,Wang L,Thorburn DR,Hirano M,Poulton J,Taylor RW,Elgar G,Martí R,Voshol P,Holt IJ,Spinazzola A

Fri Jan 01 00:00:00 UTC 2016

MPV17L2 is required for ribosome assembly in mitochondria.

Nucleic acids research

Dalla Rosa I,Durigon R,Pearce SF,Rorbach J,Hirst EM,Vidoni S,Reyes A,Brea-Calvo G,Minczuk M,Woellhaf MW,Herrmann JM,Huynen MA,Holt IJ,Spinazzola A

Tue Jul 01 00:00:00 UTC 2014

MPV17L2 is required for ribosome assembly in mitochondria.

Nucleic acids research

Dalla Rosa I,Durigon R,Pearce SF,Rorbach J,Hirst EM,Vidoni S,Reyes A,Brea-Calvo G,Minczuk M,Woellhaf MW,Herrmann JM,Huynen MA,Holt IJ,Spinazzola A

Tue Jul 01 00:00:00 UTC 2014

AAV-mediated liver-specific MPV17 expression restores mtDNA levels and prevents diet-induced liver failure.

Molecular therapy : the journal of the American Society of Gene Therapy

Bottani E,Giordano C,Civiletto G,Di Meo I,Auricchio A,Ciusani E,Marchet S,Lamperti C,d'Amati G,Viscomi C,Zeviani M

Wed Jan 01 00:00:00 UTC 2014

AAV-mediated liver-specific MPV17 expression restores mtDNA levels and prevents diet-induced liver failure.

Molecular therapy : the journal of the American Society of Gene Therapy

Bottani E,Giordano C,Civiletto G,Di Meo I,Auricchio A,Ciusani E,Marchet S,Lamperti C,d'Amati G,Viscomi C,Zeviani M

Wed Jan 01 00:00:00 UTC 2014

Mpv17 in mitochondria protects podocytes against mitochondrial dysfunction and apoptosis in vivo and in vitro.

American journal of physiology. Renal physiology

Casalena G,Krick S,Daehn I,Yu L,Ju W,Shi S,Tsai SY,D'Agati V,Lindenmeyer M,Cohen CD,Schlondorff D,Bottinger EP

Sun Jun 01 00:00:00 UTC 2014

Mpv17 in mitochondria protects podocytes against mitochondrial dysfunction and apoptosis in vivo and in vitro.

American journal of physiology. Renal physiology

Casalena G,Krick S,Daehn I,Yu L,Ju W,Shi S,Tsai SY,D'Agati V,Lindenmeyer M,Cohen CD,Schlondorff D,Bottinger EP

Sun Jun 01 00:00:00 UTC 2014

Lethal hepatopathy and leukodystrophy caused by a novel mutation in MPV17 gene: description of an alternative MPV17 spliced form.

Molecular genetics and metabolism

Navarro-Sastre A,Martín-Hernández E,Campos Y,Quintana E,Medina E,de Las Heras RS,Lluch M,Muñoz A,del Hoyo P,Martín R,Gort L,Briones P,Ribes A

Sun Jun 01 00:00:00 UTC 2008

Lethal hepatopathy and leukodystrophy caused by a novel mutation in MPV17 gene: description of an alternative MPV17 spliced form.

Molecular genetics and metabolism

Navarro-Sastre A,Martín-Hernández E,Campos Y,Quintana E,Medina E,de Las Heras RS,Lluch M,Muñoz A,del Hoyo P,Martín R,Gort L,Briones P,Ribes A

Sun Jun 01 00:00:00 UTC 2008

MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletion.

Nature genetics

Spinazzola A,Viscomi C,Fernandez-Vizarra E,Carrara F,D'Adamo P,Calvo S,Marsano RM,Donnini C,Weiher H,Strisciuglio P,Parini R,Sarzi E,Chan A,DiMauro S,Rötig A,Gasparini P,Ferrero I,Mootha VK,Tiranti V,Zeviani M

Mon May 01 00:00:00 UTC 2006

MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletion.

Nature genetics

Mon May 01 00:00:00 UTC 2006

MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletion.

Nature genetics

Mon May 01 00:00:00 UTC 2006

MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletion.

Nature genetics

Mon May 01 00:00:00 UTC 2006

Bioinformatics

Protein Aliases: h-MPV; hMPV; Mitochondrial inner membrane protein Mpv17; Mpv-17; MpV17 mitochondrial inner membrane protein; Mpv17 protein; Mpv17, human homolog of glomerulosclerosis and nephrotic syndrome; OTTHUMP00000122591; Protein Mpv17

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Gene Aliases: MPV17; MTDPS6; SYM1; Tg.Mpv17

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UniProt ID: (Human) P39210, (Mouse) P19258

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Entrez Gene ID: (Human) 4358, (Mouse) 17527

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Function(s)

molecular_function transporter

Process(es)

mitochondrial genome maintenance glomerular basement membrane development cellular response to reactive oxygen species homeostatic process inner ear development regulation of reactive oxygen species metabolic process sensory perception of sound reactive oxygen species metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MPV17 Polyclonal Antibody

MPV17 Antibody (10310-1-AP) in ICC/IF

Product Details

10310-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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