Proteintech

MPZ/P0 Polyclonal Antibody

MPZ/P0 Antibody in Immunocytochemistry (ICC/IF)

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MPZ/P0 Antibody (10572-1-AP) in ICC/IF

IF result from Huaqing Liu (PMID:20448483); Dual immunofluorescence for BrdU (red) with myelinating Schwann cell markers P0 (10572-1-AP, green, 1:150) in distal segments of MMPi-treated nerves.

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Product Details

10572-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

Assay-dependent

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:20-1:200

View 4 publications 4 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat, Xenopus

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MPZ,P0 Fusion Protein Ag0848 (1-258 aa encoded by BC006491)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody can recognize endogenous MPZ, and can be used as a marker of myelinating Schwann cells.

Immunogen sequence: MLRAPAPAP AMAPGAPSSS PSPILAVLLF SSLVLSPAQA IVVYTDREVH GAVGSRVTLH CSFWSSEWVS DDISFTWRYQ PEGGRDAISI FHYAKGQPYI DEVGTFKERI QWVGDPRWKD GSIVIHNLDY SDNGTFTCDV KNPPDIVGKT SQVTLYVFEK VPTRYGVVLG AVIGGVLGVV LLLLLLFYVV RYCWLRRQAA LQRRLSAMEK GKLHKPGKDA SKRGRQTPVL YAMLDHSRST KAVSEKKAKG LGESRKDKK (1-258 aa encoded by BC006491 )

Target Information

Zero, also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission. Zero protein encompasses approximately 50% of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin. Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e.g. G134R) can abrogate multimer formation, cause demyelinating neuropathies, and are known to contribute to conditions that include Charcot-Marie-Tooth disease. Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation, which appears to be prevalent during peak nerve myelination. Zero transcript is moderate in brain, abundant in thymus and most abundant in white matter of the CNS.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

COUP-TFII plays a role in cAMP-induced Schwann cell differentiation and in vitro myelination by up-regulating Krox20.

Journal of neurochemistry

Han SH,Kim YH,Park SJ,Cho JG,Shin YK,Hong YB,Yun J,Han JY,Park HT,Park JI

Thu Jun 01 00:00:00 UTC 2023

Jatrorrhizine ameliorates Schwann cell myelination via inhibiting HDAC3 ability to recruit Atxn2l for regulating the NRG1-ErbB2-PI3K-AKT pathway in diabetic peripheral neuropathy mice.

Phytotherapy research : PTR

Gong X,Gui Z,Ye X,Li X

Wed Feb 01 00:00:00 UTC 2023

Jatrorrhizine ameliorates Schwann cell myelination via inhibiting HDAC3 ability to recruit Atxn2l for regulating the NRG1-ErbB2-PI3K-AKT pathway in diabetic peripheral neuropathy mice.

Phytotherapy research : PTR

Gong X,Gui Z,Ye X,Li X

Wed Feb 01 00:00:00 UTC 2023

Clinical identification of expressed proteins in adrenal medullary hyperplasia detected with hypertension.

Frontiers in endocrinology

Ma H,Wang K,Lai B,Zhang X,Lv Y,Li R

Mon Jan 02 00:00:00 UTC 2023

Schwann cells promote prevascularization and osteogenesis of tissue-engineered bone via bone marrow mesenchymal stem cell-derived endothelial cells.

Stem cell research & therapy

Zhang X,Jiang X,Jiang S,Cai X,Yu S,Pei G

Wed Jul 07 00:00:00 UTC 2021

Neuroprotective Effect of Salvianolic Acid A against Diabetic Peripheral Neuropathy through Modulation of Nrf2.

Oxidative medicine and cellular longevity

Xu C,Hou B,He P,Ma P,Yang X,Yang X,Zhang L,Qiang G,Li W,Du G

Tue Nov 10 00:00:00 UTC 2020

DHTKD1 Deficiency Causes Charcot-Marie-Tooth Disease in Mice.

Molecular and cellular biology

Xu WY,Zhu H,Shen Y,Wan YH,Tu XD,Wu WT,Tang L,Zhang HX,Lu SY,Jin XL,Fei J,Wang ZG

Sun Jul 01 00:00:00 UTC 2018

DHTKD1 Deficiency Causes Charcot-Marie-Tooth Disease in Mice.

Molecular and cellular biology

Xu WY,Zhu H,Shen Y,Wan YH,Tu XD,Wu WT,Tang L,Zhang HX,Lu SY,Jin XL,Fei J,Wang ZG

Sun Jul 01 00:00:00 UTC 2018

DHTKD1 Deficiency Causes Charcot-Marie-Tooth Disease in Mice.

Molecular and cellular biology

Xu WY,Zhu H,Shen Y,Wan YH,Tu XD,Wu WT,Tang L,Zhang HX,Lu SY,Jin XL,Fei J,Wang ZG

Sun Jul 01 00:00:00 UTC 2018

DHTKD1 Deficiency Causes Charcot-Marie-Tooth Disease in Mice.

Molecular and cellular biology

Xu WY,Zhu H,Shen Y,Wan YH,Tu XD,Wu WT,Tang L,Zhang HX,Lu SY,Jin XL,Fei J,Wang ZG

Sun Jul 01 00:00:00 UTC 2018

Phylogenetically Conserved Sequences Around Myelin P0 Stop Codon are Essential for Translational Readthrough to Produce L-MPZ.

Neurochemical research

Yamaguchi Y,Baba H

Mon Jan 01 00:00:00 UTC 2018

Phylogenetically Conserved Sequences Around Myelin P0 Stop Codon are Essential for Translational Readthrough to Produce L-MPZ.

Neurochemical research

Yamaguchi Y,Baba H

Mon Jan 01 00:00:00 UTC 2018

Phylogenetically Conserved Sequences Around Myelin P0 Stop Codon are Essential for Translational Readthrough to Produce L-MPZ.

Neurochemical research

Yamaguchi Y,Baba H

Mon Jan 01 00:00:00 UTC 2018

Phylogenetically Conserved Sequences Around Myelin P0 Stop Codon are Essential for Translational Readthrough to Produce L-MPZ.

Neurochemical research

Yamaguchi Y,Baba H

Mon Jan 01 00:00:00 UTC 2018

Schwann Cell Expressed Nogo-B Modulates Axonal Branching of Adult Sensory Neurons Through the Nogo-B Receptor NgBR.

Frontiers in cellular neuroscience

Eckharter C,Junker N,Winter L,Fischer I,Fogli B,Kistner S,Pfaller K,Zheng B,Wiche G,Klimaschewski L,Schweigreiter R

Fri Dec 04 00:00:00 UTC 2015

Schwann Cell Expressed Nogo-B Modulates Axonal Branching of Adult Sensory Neurons Through the Nogo-B Receptor NgBR.

Frontiers in cellular neuroscience

Eckharter C,Junker N,Winter L,Fischer I,Fogli B,Kistner S,Pfaller K,Zheng B,Wiche G,Klimaschewski L,Schweigreiter R

Fri Dec 04 00:00:00 UTC 2015

Sensory neurons do not induce motor neuron loss in a human stem cell model of spinal muscular atrophy.

PloS one

Schwab AJ,Ebert AD

Mon Nov 16 00:00:00 UTC 2015

Sensory neurons do not induce motor neuron loss in a human stem cell model of spinal muscular atrophy.

PloS one

Schwab AJ,Ebert AD

Mon Nov 16 00:00:00 UTC 2015

Matrix metalloproteinase inhibition enhances the rate of nerve regeneration in vivo by promoting dedifferentiation and mitosis of supporting schwann cells.

Journal of neuropathology and experimental neurology

Liu H,Kim Y,Chattopadhyay S,Shubayev I,Dolkas J,Shubayev VI

Thu Apr 01 00:00:00 UTC 2010

Matrix metalloproteinase inhibition enhances the rate of nerve regeneration in vivo by promoting dedifferentiation and mitosis of supporting schwann cells.

Journal of neuropathology and experimental neurology

Liu H,Kim Y,Chattopadhyay S,Shubayev I,Dolkas J,Shubayev VI

Thu Apr 01 00:00:00 UTC 2010

MMP-9 controls Schwann cell proliferation and phenotypic remodeling via IGF-1 and ErbB receptor-mediated activation of MEK/ERK pathway.

Glia

Chattopadhyay S,Shubayev VI

Tue Sep 01 00:00:00 UTC 2009

MMP-9 controls Schwann cell proliferation and phenotypic remodeling via IGF-1 and ErbB receptor-mediated activation of MEK/ERK pathway.

Glia

Chattopadhyay S,Shubayev VI

Tue Sep 01 00:00:00 UTC 2009

MMPs initiate Schwann cell-mediated MBP degradation and mechanical nociception after nerve damage.

Molecular and cellular neurosciences

Kobayashi H,Chattopadhyay S,Kato K,Dolkas J,Kikuchi S,Myers RR,Shubayev VI

Mon Dec 01 00:00:00 UTC 2008

MMPs initiate Schwann cell-mediated MBP degradation and mechanical nociception after nerve damage.

Molecular and cellular neurosciences

Kobayashi H,Chattopadhyay S,Kato K,Dolkas J,Kikuchi S,Myers RR,Shubayev VI

Mon Dec 01 00:00:00 UTC 2008

MMPs initiate Schwann cell-mediated MBP degradation and mechanical nociception after nerve damage.

Molecular and cellular neurosciences

Kobayashi H,Chattopadhyay S,Kato K,Dolkas J,Kikuchi S,Myers RR,Shubayev VI

Mon Dec 01 00:00:00 UTC 2008

Bioinformatics

Protein Aliases: Charcot-Marie-Tooth neuropathy 1B; MPP; Myelin peripheral protein; Myelin protein P0; Myelin protein zero; myelin protein zero (Charcot-Marie-Tooth neuropathy 1B)

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Gene Aliases: CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; DSS; HMSNIB; MPP; MPZ; P-zero; P0

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UniProt ID: (Human) P25189, (Rat) P06907, (Mouse) P27573

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Entrez Gene ID: (Human) 4359, (Rat) 24564, (Mouse) 17528

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Function(s)

structural molecule activity molecular_function protein binding myelin protein

Process(es)

chemical synaptic transmission negative regulation of apoptotic process cell-cell junction maintenance

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MPZ/P0 Polyclonal Antibody

MPZ/P0 Antibody (10572-1-AP) in ICC/IF

Product Details

10572-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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