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Proteintech
MPZ/P0 Polyclonal Antibody
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Product Details
10572-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat,
Xenopus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MPZ,P0 Fusion Protein Ag0848 (1-258 aa encoded by BC006491)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody can recognize endogenous MPZ, and can be used as a marker of myelinating Schwann cells.
Immunogen sequence: MLRAPAPAP AMAPGAPSSS PSPILAVLLF SSLVLSPAQA IVVYTDREVH GAVGSRVTLH CSFWSSEWVS DDISFTWRYQ PEGGRDAISI FHYAKGQPYI DEVGTFKERI QWVGDPRWKD GSIVIHNLDY SDNGTFTCDV KNPPDIVGKT SQVTLYVFEK VPTRYGVVLG AVIGGVLGVV LLLLLLFYVV RYCWLRRQAA LQRRLSAMEK GKLHKPGKDA SKRGRQTPVL YAMLDHSRST KAVSEKKAKG LGESRKDKK (1-258 aa encoded by BC006491 )
Target Information
Zero, also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission. Zero protein encompasses approximately 50% of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin. Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e.g. G134R) can abrogate multimer formation, cause demyelinating neuropathies, and are known to contribute to conditions that include Charcot-Marie-Tooth disease. Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation, which appears to be prevalent during peak nerve myelination. Zero transcript is moderate in brain, abundant in thymus and most abundant in white matter of the CNS.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Charcot-Marie-Tooth neuropathy 1B; MPP; Myelin peripheral protein; Myelin protein P0; Myelin protein zero; myelin protein zero (Charcot-Marie-Tooth neuropathy 1B)
Gene Aliases: CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; DSS; HMSNIB; MPP; MPZ; P-zero; P0
UniProt ID: (Human) P25189, (Rat) P06907, (Mouse) P27573
Entrez Gene ID: (Human) 4359, (Rat) 24564, (Mouse) 17528
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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