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Proteintech
MPZL2 Polyclonal Antibody
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Product Details
11787-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MPZL2 Fusion Protein Ag2419 (1-215 aa encoded by BC017774)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody can be used to detect endogenous MPZL2, however, the reason for the additional band of 32 kDa is still unknown.
Immunogen sequence: MYGKSSTRA VLLLLGIQLT ALWPIAAVEI YTSRVLEAVN GTDARLKCTF SSFAPVGDAL TVTWNFRPLD GGPEQFVFYY HIDPFQPMSG RFKDRVSWDG NPERYDASIL LWKLQFDDNG TYTCQVKNPP DVDGVIGEIR LSVVHTVRFS EIHFLALAIG SACALMIIIV IVVVLFQHYR KKRWAERAHK VVEIKSKEEE RLNQEKKVSV YLEDTD (1-215 aa encoded by B C017774)
Target Information
Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Epithelial V-like antigen 1; myelin protein zero-like 2; Myelin protein zero-like protein 2
Gene Aliases: EVA; EVA1; MPZL2; UNQ606/PRO1192
UniProt ID: (Human) O60487
Entrez Gene ID: (Human) 10205, (Mouse) 14012, (Rat) 300679
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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