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Immunogen sequence: LSWLAVDNVAH TIKQAWEANQ HELLYQKNWL EEECIAWLKR FLEYGKDTLQ RTEPPLVRVN RKETFPGVTA LFCKAHG
Highest antigen sequence identity to the following orthologs - mouse 79%, rat 79%.
Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T- cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Class I histocompatibility antigen-like protein; Major histocompatibility complex class I-related gene protein; major histocompatibility complex, class I-like sequence; MHC class I-like antigen MR-1; MHC class I-related gene protein; MHC class-I related-gene protein
Gene Aliases: HLALS; MR1
UniProt ID: (Human) Q95460
Entrez Gene ID: (Human) 3140
Molecular Function:
cytokine receptor
defense/immunity protein
immunoglobulin receptor superfamily
major histocompatibility complex antigen
receptor
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