Search
Proteintech
MRAP2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
17259-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MRAP2 Fusion Protein Ag10934 (1-205 aa encoded by BC010003)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSAQRLISN RTSQQSASNS DYTWEYEYYE IGPVSFEGLK AHKYSIVIGF WVGLAVFVIF MFFVLTLLTK TGAPHQDNAE SSEKRFRMNS FVSDFGRPLE PDKVFSRQGN EESRSLFHCY INEVERLDRA KACHQTTALD SDVQLQEAIR SSGQPEEELN RLMKFDIPNF VNTDQNYFGE DDLLISEPPI VLETKPLSQT SHKDLD (1-205 aa encoded by B C010003)
Target Information
Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MC2R accessory protein 2; Melanocortin-2 receptor accessory protein 2; unnamed protein product
Gene Aliases: bA51G5.2; BB633055; C6orf117; MRAP2; RGD1309873
UniProt ID: (Human) Q96G30, (Mouse) D3Z1Q2
Entrez Gene ID: (Human) 112609, (Rat) 363112, (Mouse) 244958
energy reserve metabolic process
feeding behavior
positive regulation of cAMP biosynthetic process
protein localization to cell surface
energy homeostasis
protein localization to plasma membrane
regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
negative regulation of protein localization to plasma membrane
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support