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FIGURE: 1 / 4
MRC2 Antibody (PA5-104512) in ICC/IF
Immunocytochemistry analysis of MRC2 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with MRC2 polyclonal antibody (Product # PA5-104512) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-104512
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MRC2(Accession Q9UBG0), corresponding to amino acid residues T125-V175.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2853813
Product Specific Information
Antibody detects endogenous levels of total MRC2.
Target Information
May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-type lectin domain family 13 member E; C-type mannose receptor 2; CD280; collagen-binding factor Endo180; endocytic receptor (macrophage mannose receptor family); Endocytic receptor 180; Lectin lambda; Macrophage mannose receptor 2; mannose receptor, C type 2; novel lectin; UPAR-associated protein; Urokinase-type plasminogen activator receptor-associated protein
Gene Aliases: CD280; CLEC13E; ENDO180; KIAA0709; mKIAA0709; MRC2; UPARAP
UniProt ID: (Human) Q9UBG0, (Rat) Q4TU93, (Mouse) Q64449
Entrez Gene ID: (Human) 9902, (Rat) 498011, (Mouse) 17534
Performance Guarantee
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