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Product Details
PA5-36291
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 1630-1680 of human MRCK beta
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2553457
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 194 kDa.^M
^M
Purity is >95% by SDS-PAGE.
Target Information
CDC42BPB is a serine/threonine kinases which functions in actin cytoskeleton assembly and organization. Myotonic dystrophy kinaserelated Cdc42-binding (DMPK-like) kinases-alpha and beta (MRCK-alpha, beta) contain a cysteine-rich motif and a putative pleckstrin homology domain. MRCKs can phosphorylate nonmuscle Myosin light chain and influences Actin-Myosin contractility. MRCK-alpha can phosphorylate and activate LIM kinases downstream of Cdc42, which leads to inactivation of ADF/Cofilin and to Actin cytoskeletal reorganization. MRCK-alpha can also influence neurite outgrowth promoted by Cdc42 and Rac.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC42 binding protein kinase beta (DMPK-like); CDC42-binding protein kinase beta; CDC42-binding protein kinase beta (DMPK-like); CDC42BP-beta; CDC42BPB; cdc42bpb {ECO:0000312|EMBL:AAP34403.1}; DMPK-like beta; MRCK beta; myotonic dystrophy kinase related CDC42 binding kinase beta; Myotonic dystrophy kinase-related CDC42-binding kinase beta; myotonic dystrophy protein kinase like beta; myotonic dystrophy protein kinase-like beta; Serine/threonine-protein kinase MRCK beta
Gene Aliases: CDC42BPB; KIAA1124; MRCKB
UniProt ID: (Human) Q9Y5S2, (Rat) Q7TT49, (Mouse) Q7TT50
Entrez Gene ID: (Human) 9578, (Rat) 113960, (Mouse) 217866
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
ATP binding
Rho GTPase binding
protein binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
non-receptor serine/threonine protein kinase
protein phosphorylation
cytoskeleton organization
establishment or maintenance of cell polarity
signal transduction
cell migration
actomyosin structure organization
actin cytoskeleton reorganization
intracellular signal transduction
actin cytoskeleton organization
regulation of catalytic activity
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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