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Product Details
PA5-99655
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CDC42BPB(Accession Q9Y5S2), corresponding to amino acid residues G1645-H1695.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2818588
Product Specific Information
Antibody detects endogenous levels of total MRCKbeta.
Target Information
CDC42BPB is a serine/threonine kinases which functions in actin cytoskeleton assembly and organization. Myotonic dystrophy kinaserelated Cdc42-binding (DMPK-like) kinases-alpha and beta (MRCK-alpha, beta) contain a cysteine-rich motif and a putative pleckstrin homology domain. MRCKs can phosphorylate nonmuscle Myosin light chain and influences Actin-Myosin contractility. MRCK-alpha can phosphorylate and activate LIM kinases downstream of Cdc42, which leads to inactivation of ADF/Cofilin and to Actin cytoskeletal reorganization. MRCK-alpha can also influence neurite outgrowth promoted by Cdc42 and Rac.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC42 binding protein kinase beta (DMPK-like); CDC42-binding protein kinase beta; CDC42-binding protein kinase beta (DMPK-like); CDC42BP-beta; CDC42BPB; DMPK-like beta; MRCK beta; Myotonic dystrophy kinase-related CDC42-binding kinase beta; myotonic dystrophy protein kinase-like beta; Serine/threonine-protein kinase MRCK beta
Gene Aliases: CDC42BPB; KIAA1124; MRCKB
UniProt ID: (Human) Q9Y5S2
Entrez Gene ID: (Human) 9578
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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