This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
This Mre11 antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry on paraffin-embedded sections (PMID 21279473) Immunoprecipitation and Western Blot.
In WB, a band can be seen at ~81 kDa.
For ICC/IF, this antibody has been used with methanol-fixed IMR90 primary human fibroblasts. For IP, the suggested working dilution is 3 µL for immunoprecipitation of 3X10^6 cells.
Co-IP application has been reported by Ching et al 2012 (PMID: 22190719).
Suggested positive control: antigen standard for MRE11A (transient overexpression lysate), Hela whole cell extract, Hela whole cell lysate.
MRE11 (double-strand break repair protein MRE11) is a component of the MRN complex. This complex plays a central role in double-strand break repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-stranded endonuclease activity and double-strand-specific 3'-5' exonuclease activity which are provided by MRE11. RAD50 is required to bind DNA ends and hold them in close proximity. Mutations in the gene could result in ataxia-telangiectasia-like disorder 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AT-like disease; Ataxia-telangiectasia disorder-like; ATLD; DNA recombination and repair protein; Double-strand break repair protein MRE11; Double-strand break repair protein MRE11A; endo/exonuclease Mre11; Meiotic recombination 11 homolog 1; Meiotic recombination 11 homolog A; MmMRE11A; MRE11 double strand break repair nuclease A; MRE11 homolog 1; MRE11 homolog A; MRE11 homolog, double strand break repair nuclease A; MRE11 meiotic recombination 11 homolog A; MRE11 meiotic recombination 11 homolog A (S. cerevisiae); MRE11 meiotic recombination 11-like protein A; MRE11a; MRE11b
Gene Aliases: ATLD; HNGS1; MRE11; MRE11A; MRE11B