Search
Invitrogen
MRE11 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 4
MRE11 Antibody (PA5-78063) in ICC/IF
MRE11 Polyclonal Antibody [C1C3-2] detects Mre11 protein at nucleus by immunofluorescent analysis. Sample: SKNSH cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Mre11 protein stained by MRE11 Polyclonal Antibody [C1C3-2] (Product # PA5-78063) diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10 μm.
Product Details
PA5-78063
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human Mre11. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.57 mg/mL
Amount
57 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: HeLa, IMR32
Predicted Reactivity: Mouse (86%), Rat (86%), Bovine (90%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
MRE11 (double-strand break repair protein MRE11) is a component of the MRN complex. This complex plays a central role in double-strand break repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-stranded endonuclease activity and double-strand-specific 3'-5' exonuclease activity which are provided by MRE11. RAD50 is required to bind DNA ends and hold them in close proximity. Mutations in the gene could result in ataxia-telangiectasia-like disorder 1.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: AT-like disease; DNA recombination and repair protein; Double-strand break repair protein MRE11; double-strand break repair protein MRE11A; endo/exonuclease Mre11; hMRE11B; Mre11 homolog; Meiotic recombination 11 homolog 1; Meiotic recombination 11 homolog A; MRE11 double strand break repair nuclease A; MRE11 homolog 1; MRE11 homolog A; MRE11 homolog A, double strand break repair nuclease; MRE11 homolog, double strand break repair nuclease A; MRE11 meiotic recombination 11 homolog A; MRE11 meiotic recombination 11 homolog A (S. cerevisiae) isoform MRE11A_1; MRE11 meiotic recombination 11 homolog A (S. cerevisiae) isoform MRE11A_2; MRE11 meiotic recombination 11-like protein A; unnamed protein product
Gene Aliases: ATLD; HNGS1; MRE11; MRE11A; MRE11B
UniProt ID: (Human) P49959
Entrez Gene ID: (Human) 4361
single-stranded DNA endodeoxyribonuclease activity
DNA binding
DNA helicase activity
double-stranded DNA binding
nuclease activity
endonuclease activity
endodeoxyribonuclease activity
exonuclease activity
protein binding
3'-5'-exodeoxyribonuclease activity
3'-5' exonuclease activity
hydrolase activity
manganese ion binding
identical protein binding
cadherin binding
regulation of mitotic recombination
telomere maintenance
double-strand break repair via homologous recombination
DNA double-strand break processing
DNA repair
double-strand break repair
double-strand break repair via nonhomologous end joining
DNA recombination
cellular response to DNA damage stimulus
telomere maintenance via telomerase
sister chromatid cohesion
mitotic G2 DNA damage checkpoint
synapsis
reciprocal meiotic recombination
cell proliferation
intra-S DNA damage checkpoint
telomeric 3' overhang formation
positive regulation of telomere maintenance
reciprocal DNA recombination
meiotic DNA double-strand break formation
negative regulation of apoptotic process
mitotic G2/M transition checkpoint
chromosome organization
meiotic cell cycle
R-loop processing
mitochondrial double-strand break repair via homologous recombination
DNA strand resection involved in replication fork processing
positive regulation of double-strand break repair
negative regulation of double-strand break repair via nonhomologous end joining
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support