Search

  • Contact Us
  • Quick Order

Fabgennix

MRP1 Polyclonal Antibody

View all (23) MRP1 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
{{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation']}}:

{{$ctrl.translations[$ctrl.isSkuNotesCollapsed ? 'antibody.pdp.skuNotes.viewMore' : 'antibody.pdp.skuNotes.viewLess']}}

Product Details

MRP1-101AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to unique amino acid sequences on rat multidrug resistance-associated protein 1.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: ABC-transporter; MRP; ABCC1; ATP-binding cassette sub-family C ( CFTR/MRP) member 1a; ATP-binding cassette sub-family C member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1a; ATP-binding cassette, sub-family C (CFTR/MRP), member 1b; ATP-binding cassette, sub-family C, member 1-like; ATP-binding cassette, subfamily C (CFTR/MRP), member 1; DKFZp686N04233; DKFZp781G125; glutathione-S-conjugate-translocating ATPase ABCC1; leuk; leukotriene C(4) transporter; LTC4 transporter; multidrug resistance protein 1; multidrug resistance-associated protein 1-like; multiple drug resistance-associated protein; unnamed protein product

View more View less

Gene Aliases: Abcc1a; Abcc1b; Avcc1a; Mdrap; MRP; Mrp1

View more View less

UniProt ID: (Rat) Q8CG09, (Mouse) O35379

View more View less

Entrez Gene ID: (Rat) 24565, (Mouse) 17250

View more View less

Function(s)
long-chain fatty acid transporter activity ATP binding xenobiotic-transporting ATPase activity cobalamin-transporting ATPase activity glutathione S-conjugate-exporting ATPase activity efflux transmembrane transporter activity oxidoreductase activity ATPase activity transmembrane transporter activity lipid-transporting ATPase activity glutathione transmembrane transporter activity xenobiotic transporter activity carboxylic acid transmembrane transporter activity ABC-type transporter activity
Process(es)
tissue homeostasis granuloma formation inflammatory response to antigenic stimulus endothelium development leukotriene metabolic process glutathione metabolic process lipid transport apoptotic process inflammatory response immune response cellular response to DNA damage stimulus response to oxidative stress memory glucocorticoid metabolic process response to xenobiotic stimulus response to toxic substance glial cell differentiation gene expression monocarboxylic acid transport bilirubin transport cobalamin transport plasma membrane long-chain fatty acid transport leukotriene biosynthetic process amygdala development hippocampus development neurogenesis positive regulation of cell migration phospholipid efflux response to interferon-gamma protein localization to cell surface response to fluid shear stress glutathione transport glutathione transmembrane transport multicellular organism growth exploration behavior macrophage activation vasodilation regulation of membrane potential superoxide anion generation xenobiotic transport pigment accumulation fibroblast apoptotic process phospholipid translocation cell redox homeostasis tetrahydrobiopterin metabolic process antigen processing and presentation of lipid antigen via MHC class Ib astrocyte differentiation beta-amyloid metabolic process hydrogen peroxide biosynthetic process positive regulation of inflammatory response regulation of catalytic activity defense response to Gram-positive bacterium NK T cell activation response to glucocorticoid cellular chemical homeostasis transmembrane transport cell chemotaxis transepithelial transport cyclic nucleotide transport cellular response to interferon-gamma leukotriene transport endothelial cell apoptotic process lymphocyte migration beta-amyloid clearance neural tissue regeneration regulation of blood vessel diameter sphingolipid translocation export across plasma membrane export from cell intracellular nitrogen homeostasis reactive oxygen species biosynthetic process cellular response to beta-amyloid carboxylic acid transmembrane transport drug transmembrane export drug transport across blood-brain barrier regulation of cellular response to drug drug transmembrane transport
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support