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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 230 and 325 of Human MRP1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 2 publications below|
PA5-30594 targets MRP1 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-30594 immunogen is synthetic peptide corresponding to a region within amino acids 230 and 325 of Human MRP1.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Metformin reverses multidrug resistance in human hepatocellular carcinoma Bel‑7402/5‑fluorouracil cells.
PA5-30594 was used in western blot to determine if metformin reverses the multidrug resistance observed in human hepatocellular carcinoma Bel-7402/5-fluorouracil cells
|Ling S,Tian Y,Zhang H,Jia K,Feng T,Sun D,Gao Z,Xu F,Hou Z,Li Y,Wang L||Molecular medicine reports (10:2891)||2014|
Metformin inhibits proliferation and enhances chemosensitivity of intrahepatic cholangiocarcinoma cell lines.
PA5-30594 was used in western blot to determine if metformin could be used to treat intrahepatic cholangiocarcinoma
|Ling S,Feng T,Ke Q,Fan N,Li L,Li Z,Dong C,Wang C,Xu F,Li Y,Wang L||Oncology reports (31:2611)||2014|
ABC29; ABCC; ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding cassette transporter variant ABCC1delta-ex13&14; ATP-binding cassette transporter variant ABCC1delta-ex25; ATP-binding cassette transporter variant ABCC1delta-ex25&26; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; GS-X; leuk; leukotriene C(4) transporter; LTC4 transporter; MRP; MRP1
ABC29; ABCC; ABCC1; GS-X; MRP; MRP1