Immunogen sequence: GSYQELLARD GAFAEFLRTY ASTEQEQDAE ENGVTGVSGP GKEAKQMENG MLVTDSAGKQ LQRQLSSSSS YSGDISRHHN STAELQKAEA KKEETWKLME ADKAQTGQVK L; Positive Samples: HepG2; Cellular Location: Cell membrane, Multi-pass membrane protein
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.
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Protein Aliases: ATP-binding cassette sub-family C ( CFTR/MRP) member 1a; ATP-binding cassette sub-family C member 1; ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding cassette transporter variant ABCC1delta-ex13 and 14; ATP-binding cassette transporter variant ABCC1delta-ex25; ATP-binding cassette transporter variant ABCC1delta-ex25 and 26; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; Leukotriene C(4) transporter; LTC4 transporter; multidrug resistance protein 1; Multidrug resistance-associated protein 1; multiple drug resistance-associated protein
Gene Aliases: ABC29; ABCC; ABCC1; Abcc1a; Avcc1a; GS-X; MRP; MRP1