Search
Invitrogen
MRP2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 2
MRP2 Antibody (PA5-97038) in WB
Western blot analysis of MRP2 in extracts of various cell lines. Samples were incubated with MRP2 Polyclonal antibody (Product # PA5-97038) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-97038
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 180-315 of human MRP2/ABCC2 (NP_0003831)
Conjugate
Form
Liquid
Concentration
1.35 mg/mL
Amount
135 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: HepG2, 293T, HeLa, A-549, BT-474; Cellular Location: Apical cell membrane, Multi-pass membrane protein
Immunogen sequence: IFSAFSENNE SSNNPSSIAS FLSSITYSWY DSIILKGYKR PLTLEDVWEV DEEMKTKTLV SKFETHMKRE LQKARRALQR RQEKSSQQNS GARLPGLNKN QSQSQDALVL EDVEKKKKKS GTKKDVPKSW LMKALF
Target Information
This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: ATP-binding cassette sub-family C member 2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; calicular multispecific organic anion transporter; Canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; Human MRP2; KIAA1010; multidrug resistance associated protein 2; multidrug resistance protein 2; Multidrug resistance-associated protein 2
Gene Aliases: ABC30; ABCC2; AI173996; CMOAT; CMOAT1; CMRP; DJS; MRP2
UniProt ID: (Human) Q92887, (Rat) Q63120, (Mouse) Q8VI47
Entrez Gene ID: (Human) 1244, (Rat) 25303, (Mouse) 12780
nucleotide binding
protein binding
ATP binding
organic anion transmembrane transporter activity
xenobiotic-transporting ATPase activity
bilirubin transmembrane transporter activity
glutathione S-conjugate-exporting ATPase activity
ATPase activity
transmembrane transporter activity
ATPase activity, coupled to transmembrane movement of substances
xenobiotic transporter activity
anion transmembrane-transporting ATPase activity
ABC-type transporter activity
protein domain specific binding
ATP-binding cassette (ABC) transporter
xenobiotic metabolic process
drug transmembrane transport
lipid transport
negative regulation of gene expression
bile acid and bile salt transport
bilirubin transport
heme catabolic process
drug export
carboxylic acid transport
transmembrane transport
transepithelial transport
leukotriene transport
anion transmembrane transport
transport across blood-brain barrier
drug transport across blood-brain barrier
response to oxidative stress
metabolic process
response to heat
organic anion transport
prostaglandin transport
cellular chloride ion homeostasis
response to methotrexate
response to drug
response to estrogen
response to arsenic-containing substance
response to steroid hormone
thyroid hormone transport
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support