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Invitrogen
MRP3 Polyclonal Antibody
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Product Details
PA5-101482
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ABCC3(Accession O15438), corresponding to amino acid residues L977-M1027.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ABCC3.
Target Information
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATP-binding cassette sub-family C member 3; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; Canalicular multispecific organic anion transporter 2; canicular multispecific organic anion transporter; cMOAT2/MRP3; DKFZp686E22157; homolog of the multidrug resistance-associated protein MRP1; MLP-2; MOAT-D; MRP transporter family; MRP-like protein 2; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter D; multidrug resistance associated protein; multidrug resistance protein 3; Multidrug resistance-associated protein 3; organic anion transporter; similar to multidrug resistance protein MRP3
Gene Aliases: ABC31; ABCC3; CMOAT2; EST90757; MLP2; MOAT-D; MRP3
UniProt ID: (Human) O15438, (Rat) O88563
Entrez Gene ID: (Human) 8714, (Rat) 140668
nucleotide binding
ATP binding
xenobiotic-transporting ATPase activity
glucuronoside transmembrane transporter activity
glutathione S-conjugate-exporting ATPase activity
bile acid-exporting ATPase activity
ATPase activity
transmembrane transporter activity
ATPase activity, coupled to transmembrane movement of substances
xenobiotic transporter activity
anion transmembrane-transporting ATPase activity
icosanoid transmembrane transporter activity
ABC-type transporter activity
drug transmembrane transporter activity
ATP-binding cassette (ABC) transporter
xenobiotic metabolic process
drug transmembrane transport
lipid transport
bile acid and bile salt transport
glucuronoside transport
xenobiotic transport
carboxylic acid transport
transmembrane transport
leukotriene transport
anion transmembrane transport
transport across blood-brain barrier
metabolic process
response to organic substance
response to organonitrogen compound
response to organic cyclic compound
canalicular bile acid transport
drug transport
response to estradiol
response to lipopolysaccharide
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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