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MRP4 Antibody (PA5-120801) in IHC (P)
Immunohistochemistry analysis of MRP4 in paraffin-embedded human prostate cancer. Samples were incubated with MRP4 Polyclonal antibody (Product # PA5-120801) using a dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
PA5-120801
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1067-1325 of human MRP4/ABCC4 (NP_005836.2).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2914373
Product Specific Information
Positive test controls include: HeLa, HeLa Cytoplasm extracts, 293T. The target is usually found in the following locations: Membrane, Multi-pass membrane protein.^M
^M
Immunogen sequence: SQEKVGIVGR TGAGKSSLIS ALFRLSEPEG KIWIDKILTT EIGLHDLRKK MSIIPQEPVL FTGTMRKNLD PFNEHTDEEL WNALQEVQLK ETIEDLPGKM DTELAESGSN FSVGQRQLVC LARAILRKNQ ILIIDEATAN VDPRTDELIQ KKIREKFAHC TVLTIAHRLN TIIDSDKIMV LDSGRLKEYD EPYVLLQNKE SLFYKMVQQL GKAEAAALTE TAKQVYFKRN YPHIGHTDHM VTNTSNGQPS TLTIFETAL
Target Information
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies. This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABC-tranporter; ATP-binding cassette protein C4; ATP-binding cassette sub-family C member 4; ATP-binding cassette subfamily C member 4; ATP-binding cassette, sub-family C (CFTR/MRP), member 4; bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4); canalicular multispecific organic anion transporter (ABC superfamily); EST170205; MOAT-B; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; Multidrug resistance-associated protein 4; RP11-74A12.1
Gene Aliases: ABCC4; D630049P08Rik; MOAT-B; MOATB; MRP4
UniProt ID: (Human) O15439, (Rat) F1M3J4, (Mouse) E9Q236
Entrez Gene ID: (Human) 10257, (Rat) 170924, (Mouse) 239273
ATP binding
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
15-hydroxyprostaglandin dehydrogenase (NAD+) activity
anion transmembrane-transporting ATPase activity
molecular_function
ATPase activity, coupled to transmembrane movement of substances
drug transmembrane transporter activity
ATP-binding cassette (ABC) transporter
platelet degranulation
biological_process
prostaglandin secretion
cilium assembly
transmembrane transport
oxidation-reduction process
anion transmembrane transport
metabolic process
response to organic substance
response to organonitrogen compound
response to organic cyclic compound
response to drug
positive regulation of smooth muscle cell proliferation
drug transmembrane transport
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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