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MRP5/ABCC5 Polyclonal Antibody
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Product Details
BS-1437R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human MRP5, amino acids 61-180.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABC 33; ABC transporter protein; ABCC 5; ABCC5_v2; ATP-binding cassette, sub-family C (CFTR/MRP), member 5, variant 2; ABCC5_v3; ATP-binding cassette, sub-family C (CFTR/MRP), member 5, variant 3; ABCC5_v4; ATP-binding cassette, sub-family C (CFTR/MRP), member 5, variant 4; ATP-binding cassette sub-family C (CFTR/MRP) member 5a; ATP-binding cassette sub-family C member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5a; ATP-binding cassette, sub-family C (CFTR/MRP), member 5b; ATP-binding cassette, sub-family C, member 5; canalicular multispecific organic anion transporter C; DKFZp686C1782; MOAT C; MOAT-C; MRP 5; MRP/cMOAT-related ABC transporter; MRP5; Multi-specific organic anion transporter C; Multidrug resistance-associated protein 5; pABC 11; pABC11; pABC11; MOAT-C; MRP5; SMRP; transporter
Gene Aliases: 2900011L11Rik; ABC33; ABCC5; Abcc5a; Abcc5b; AI132311; EST277145; MOAT-C; MOATC; MRP5; pABC11; SMRP
UniProt ID: (Human) O15440, (Rat) Q9QYM0, (Mouse) Q9R1X5
Entrez Gene ID: (Human) 10057, (Rat) 116721, (Mouse) 27416
nucleotide binding
ATP binding
organic anion transmembrane transporter activity
xenobiotic-transporting ATPase activity
purine nucleotide transmembrane transporter activity
heme transporter activity
efflux transmembrane transporter activity
ATPase activity
macromolecule transmembrane transporter activity
glutathione transmembrane transporter activity
ATPase activity, coupled to transmembrane movement of substances
xenobiotic transporter activity
anion transmembrane-transporting ATPase activity
ABC-type transporter activity
carbohydrate derivative transmembrane transporter activity
molecular_function
ATP-binding cassette (ABC) transporter
xenobiotic metabolic process
drug transmembrane transport
purine nucleotide transport
hyaluronan biosynthetic process
glutathione transmembrane transport
heme transmembrane transport
xenobiotic transport
transmembrane transport
cAMP transport
cGMP transport
anion transmembrane transport
reduced folate transmembrane transport
export across plasma membrane
transport across blood-brain barrier
drug transmembrane export
metabolic process
organic anion transport
response to lipopolysaccharide
response to insulin
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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