Immunogen sequence: SPGYRSVRER TSTSGTHRDR EDSKFRRTRP LECQDALETA ARAEGLSLDA SMHSQLRILD EEHPKGKYHH GLSALKPIRT TSKHQHPVDN AGLFSCMTFS WLSSLARVAH KKGELSMEDV WSLSKHESSD VNCRRLERL
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.
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Protein Aliases: ABC 33; ABCC 5; ATP-binding cassette sub-family C member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; canalicular multispecific organic anion transporter C; DKFZp686C1782; MOAT C; MOAT-C; MRP 5; Multi-specific organic anion transporter C; Multidrug resistance-associated protein 5; pABC 11; pABC11; SMRP
Gene Aliases: ABC33; ABCC5; EST277145; MOAT-C; MOATC; MRP5; pABC11; SMRP
UniProt ID: (Human) O15440
Entrez Gene ID: (Human) 10057
Molecular Function: ATP-binding cassette (ABC) transporter