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Invitrogen
MRP7 Polyclonal Antibody
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FIGURE: 1 / 3
MRP7 Antibody (PA5-75402) in WB
Western blot analysis of MRP7 in Lane 1: HEK293T whole cell lysate (40 µg), Lane 2: A549 whole cell lysate (40 µg), Lane 3: the Spleen tissue lysate of mouse (40 µg), Lane 4: SGC7901 whole cell lysate (40 µg), Lane 5: H9C2 whole cell lysate (40 µg). Samples were incubated with MRP7 polyclonal antibody (Product # PA5-75402) at a dilution of 1:500.
Product Details
PA5-75402
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 834-887 of Human MRP7.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
The MRP family is represented by nine similar ABC transporters that have the ability to transport structurally diverse lipophilic anions and operate as chemical efflux pumps. MRP7 (multidrug resistance-associated protein 7, ATPbinding cassette sub-family C member 10) is a multi-pass membrane protein that belongs to the ABC transporter family (conjugate transporter subfamily). MRP7 is involved with the ATP-dependent transport of 17β-estradiol-D-17-β-glucuronide (E217βG). MRP7 is also probably involved in cellular detoxification through its lipophilic anion extrusion capabilities. MRP7 contains two ABC transmembrane type 1 domains and two ABC transporter domains. MRP7 likely has three isoforms. Isoform 2 is the most widely expressed, while isoform 1 is predominately expressed in the spleen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATP-binding cassette sub-family C member 10; ATP-binding cassette, sub-family C (CFTR/MRP), member 10; Multidrug resistance-associated protein 7; transporter
Gene Aliases: ABCC10; EST182763; mFLJ00002; MRP7; SIMRP7
UniProt ID: (Human) Q5T3U5, (Mouse) Q8R4P9
Entrez Gene ID: (Human) 89845, (Rat) 316231, (Mouse) 224814
nucleotide binding
ATP binding
xenobiotic-transporting ATPase activity
glutathione S-conjugate-exporting ATPase activity
ATPase activity
xenobiotic transporter activity
anion transmembrane-transporting ATPase activity
ABC-type transporter activity
molecular_function
ATPase activity, coupled to transmembrane movement of substances
ATP-binding cassette (ABC) transporter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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