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Immunogen sequence: MPLHKYPVW LWKRLQLREG ICSRLPGYYL RSLEEERTPT PVHYRPHGAK FKINPKNGQR ERVEDVPIPI YFPPESQRGL WGGEGWILGQ IYANNDKLSK RLKKVWKPQL FEREFYSEIL DKKFTVTVTM RTLDLIDEAY GLDFYILKTP KEDLCSKFGM DLKRGMLLRL ARQDPQLHPE DPERRAAIYD KYKEFAIPEE EAEWVGLTLE EAIEKQRLLE EKDPVPLFKI YVAELIQQLQ QQALSEPAVV QKRASGQ (1-256 aa encoded by BC000990)
MRP-L28 (39S ribosomal protein L28, melanoma-associated antigen recognized by T lymphocytes) is a mitochondrial protein that belongs to the ribosomal protein L28P family. MRP-L28 potentially represents an important therapeutic reagent for HLA-A24 (A24) patients as this antigen is recognized by tumor-infiltrating lymphocyte (TIL) 1290, which targets the A24 serotype. HLAA24 (A24) is an HLA-A serotype that identifies the more common HLA-A24 gene products. A24 is a split antigen that is also recognized by the A9 broad antigen type and the similar A23 types. A24 is common in Austronesia and has one of the highest A allele frequencies for a number of peoples, including Papua New Guineans, indigeonous Taiwanese (eastern tribals), Yupik and Greenland Eskimos. MRP-L28 is found in a variety of normal tissues including spleen, testis, thymus, liver, kidney, brain, adrenal, lung and retinal tissue.
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Protein Aliases: 39S ribosomal protein L28, mitochondrial; HGNC6756; L28mt; MAAT 1; Melanoma antigen p15; melanoma-associated antigen recognised by cytotoxic T lymphocytes; melanoma-associated antigen recognized by T lymphocytes; Melanoma-associated antigen recognized by T-lymphocytes; MGC8499; Mitochondrial large ribosomal subunit protein bL28m; mitochondrial ribosomal protein L28; MRP L28; MRP-L28; MRPL 28
Gene Aliases: 1110015G04Rik; L28mt; MAAT1; MRP-L28; MRPL28; p15