Proteintech

MRPL37 Polyclonal Antibody

MRPL37 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MRPL37 Antibody (15190-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human lymphoma tissue slide using (Product # 15190-1-AP) (MRPL37 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

15190-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MRPL37 Fusion Protein Ag7276 (118-423 aa encoded by BC000041)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: KQALWLTKT KLIEGLPEKV LSLVDDPRNH IENQDECVLN VISHARLWQT TEEIPKRETY CPVIVDNLIQ LCKSQILKHP SLARRICVQN STFSATWNRE SLLLQVRGSG GARLSTKDPL PTIASREEIE ATKNHVLETF YPISPIIDLH ECNIYDVKND TGFQEGYPYP YPHTLYLLDK ANLRPHRLQP DQLRAKMILF AFGSALAQAR LLYGNDAKVL EQPVVVQSVG TDGRVFHFLV FQLNTTDLDC NEGVKNLAWV DSDQLLYQHF WCLPVIKKRV VVEPVGPVGF KPETFRKFLA LYLHGAA (118-423 aa encoded by BC000041 )

Target Information

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mitochondrial mistranslation modulated by metabolic stress causes cardiovascular disease and reduced lifespan.

Aging cell

Richman TR,Ermer JA,Siira SJ,Kuznetsova I,Brosnan CA,Rossetti G,Baker J,Perks KL,Cserne Szappanos H,Viola HM,Gray N,Larance M,Hool LC,Zuryn S,Rackham O,Filipovska A

Thu Jul 01 00:00:00 UTC 2021

A variant in MRPS14 (uS14m) causes perinatal hypertrophic cardiomyopathy with neonatal lactic acidosis, growth retardation, dysmorphic features and neurological involvement.

Human molecular genetics

Jackson CB,Huemer M,Bolognini R,Martin F,Szinnai G,Donner BC,Richter U,Battersby BJ,Nuoffer JM,Suomalainen A,Schaller A

Fri Feb 15 00:00:00 UTC 2019

A variant in MRPS14 (uS14m) causes perinatal hypertrophic cardiomyopathy with neonatal lactic acidosis, growth retardation, dysmorphic features and neurological involvement.

Human molecular genetics

Jackson CB,Huemer M,Bolognini R,Martin F,Szinnai G,Donner BC,Richter U,Battersby BJ,Nuoffer JM,Suomalainen A,Schaller A

Fri Feb 15 00:00:00 UTC 2019

Fidelity of translation initiation is required for coordinated respiratory complex assembly.

Science advances

Rudler DL,Hughes LA,Perks KL,Richman TR,Kuznetsova I,Ermer JA,Abudulai LN,Shearwood AJ,Viola HM,Hool LC,Siira SJ,Rackham O,Filipovska A

Sun Dec 01 00:00:00 UTC 2019

Stress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation.

The EMBO journal

Ferreira N,Perks KL,Rossetti G,Rudler DL,Hughes LA,Ermer JA,Scott LH,Kuznetsova I,Richman TR,Narayana VK,Abudulai LN,Shearwood AJ,Cserne Szappanos H,Tull D,Yeoh GC,Hool LC,Filipovska A,Rackham O

Mon Dec 16 00:00:00 UTC 2019

Concerted regulation of mitochondrial and nuclear non-coding RNAs by a dual-targeted RNase Z.

EMBO reports

Siira SJ,Rossetti G,Richman TR,Perks K,Ermer JA,Kuznetsova I,Hughes L,Shearwood AJ,Viola HM,Hool LC,Rackham O,Filipovska A

Mon Oct 01 00:00:00 UTC 2018

Concerted regulation of mitochondrial and nuclear non-coding RNAs by a dual-targeted RNase Z.

EMBO reports

Siira SJ,Rossetti G,Richman TR,Perks K,Ermer JA,Kuznetsova I,Hughes L,Shearwood AJ,Viola HM,Hool LC,Rackham O,Filipovska A

Mon Oct 01 00:00:00 UTC 2018

Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome.

American journal of human genetics

Lake NJ,Webb BD,Stroud DA,Richman TR,Ruzzenente B,Compton AG,Mountford HS,Pulman J,Zangarelli C,Rio M,Boddaert N,Assouline Z,Sherpa MD,Schadt EE,Houten SM,Byrnes J,McCormick EM,Zolkipli-Cunningham Z,Haude K,Zhang Z,Retterer K,Bai R,Calvo SE,Mootha VK,Christodoulou J,Rötig A,Filipovska A,Cristian I,Falk MJ,Metodiev MD,Thorburn DR

Thu Aug 03 00:00:00 UTC 2017

Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome.

American journal of human genetics

Thu Aug 03 00:00:00 UTC 2017

Adult-onset obesity is triggered by impaired mitochondrial gene expression.

Science advances

Perks KL,Ferreira N,Richman TR,Ermer JA,Kuznetsova I,Shearwood AJ,Lee RG,Viola HM,Johnstone VPA,Matthews V,Hool LC,Rackham O,Filipovska A

Tue Aug 01 00:00:00 UTC 2017

Adult-onset obesity is triggered by impaired mitochondrial gene expression.

Science advances

Perks KL,Ferreira N,Richman TR,Ermer JA,Kuznetsova I,Shearwood AJ,Lee RG,Viola HM,Johnstone VPA,Matthews V,Hool LC,Rackham O,Filipovska A

Tue Aug 01 00:00:00 UTC 2017

Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly.

Cell reports

Rackham O,Busch JD,Matic S,Siira SJ,Kuznetsova I,Atanassov I,Ermer JA,Shearwood AM,Richman TR,Stewart JB,Mourier A,Milenkovic D,Larsson NG,Filipovska A

Tue Aug 16 00:00:00 UTC 2016

Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly.

Cell reports

Rackham O,Busch JD,Matic S,Siira SJ,Kuznetsova I,Atanassov I,Ermer JA,Shearwood AM,Richman TR,Stewart JB,Mourier A,Milenkovic D,Larsson NG,Filipovska A

Tue Aug 16 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: 39S ribosomal protein L2, mitochondrial; 39S ribosomal protein L37, mitochondrial; L2mt; L37mt; Large ribosomal subunit protein mL37; MGC878; MRP-L37; ribosomal protein, mitochondrial, L2

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Gene Aliases: 2300004O14Rik; AI132596; HSPC235; L37mt; MRP-L2; MRP-L37; MRPL2; MRPL37; RPML2

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UniProt ID: (Human) Q9BZE1, (Rat) Q6AXT0, (Mouse) Q921S7

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Entrez Gene ID: (Human) 51253, (Rat) 56281, (Mouse) 56280

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Function(s)

structural constituent of ribosome poly(A) RNA binding ribosomal protein translational protein

Process(es)

translation mitochondrial translational elongation mitochondrial translational termination biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MRPL37 Polyclonal Antibody

MRPL37 Antibody (15190-1-AP) in IHC (P)

Product Details

15190-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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