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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.
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Protein Aliases: 39S ribosomal protein L46, mitochondrial; L46mt; Mitochondrial large ribosomal subunit protein mL46; MRP-L46; P2ECSL
Gene Aliases: 3110052F15Rik; C15orf4; C80107; LIECG2; MRPL46; P2ECSL
UniProt ID: (Human) Q9H2W6, (Rat) Q5RK00, (Mouse) Q9EQI8
Entrez Gene ID: (Human) 26589, (Rat) 293054, (Mouse) 67308
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