Immunogen sequence: KPIYSVGGIL LSISRPYKTK PTHGIGKYKH LIKAEEPKKK KGKVEVRAIN LGTDYEYGVL NIHLTAYDMT LAESYAQYVH NLCNS
Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 79%.
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 6p.
Protein Aliases: 39S ribosomal protein L48, mitochondrial; L48mt; MGC13323; Mitochondrial large ribosomal subunit protein mL48
Gene Aliases: CGI-118; HSPC290; L48MT; MRP-L48; MRPL48
UniProt ID: (Human) Q96GC5
Entrez Gene ID: (Human) 51642