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Antibody detects endogenous levels of total MRPL50.
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a putative 39S subunit protein and belongs to the L47P ribosomal protein family. Pseudogenes corresponding to this gene are found on chromosomes 2p, 2q, 5p, and 10q. [provided by RefSeq, Jul 2008].
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Protein Aliases: 39S ribosomal protein L50, mitochondrial; L50mt; Large ribosomal subunit protein mL50; mitochondrial 39S ribosomal protein L50
Gene Aliases: MRP-L50; MRPL50
UniProt ID: (Human) Q8N5N7
Entrez Gene ID: (Human) 54534
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